The Esco Cytoculture® Cytotoxic Safety Cabinet | Esco Pharma

The Esco Cytoculture® Cytotoxic Safety Cabinet is the premium solution for cytotoxic/antineoplastic drug processing, providing the highest level of patient, operator, & environmental protection. This revolutionary product builds on Esco’s experience of more than 20 yrs as a global leader in biological safety containment technology.

This is a short demonstration of how to properly use the cytoculture cytotoxic safety cabinet.

Cytotoxic or Antineoplastic drugs are considered hazardous. According to NIOSH, drugs considered as hazardous include those that exhibit one or more of the following six characteristics in humans or animals:
• Carcinogenicity
• Teratogenicity
• Reproductive Toxicity
• Organ Toxicity at Low Doses
• Genotoxicity
Structure & toxicity profiles of new drugs that mimic existing drugs determine hazardous by the above criteria.

It is therefore critical that anyone who handles these drugs is adequately protected & must observe safety procedures. The CYT is not a magic box. Therefore aseptic technique is still necessary for protecting the product & the operator from the risk of contamination.
✔ The CYT must be used only for handling & compounding cytotoxic drugs.
✔ CYT must also be placed in a room designated for this purpose only.

Pre-compounding procedures:
✅ Wash hands thoroughly before starting any procedure.
✅ Wear proper PPE for handling cytotoxic drugs prior to entering the
compounding room. Click the link below to know more about proper PPE donning & doffing: https://www.cdc.gov/hai/pdfs/ppe/ppe-sequence.pdf

Startup Operation:
• Raise the sash to the indicated normal operational height. The lamp will turn on when the height is reached.
• Turn on the fan by pressing the fan button. Input the fan pin. Turning on the fan will also start the warm-up procedure. During the warmup procedure, all the buttons are not operational.
• Allow the cabinet to purge any contaminant by allowing the blower to operate at least 3 minutes before & after using the cabinet. This is to
remove the airborne contaminants from the work zone & stabilize the
cabinet airflow.
• Surface decontaminate the work area before using the cabinet to ensure that the air intake & exhaust area of the cabinet are free from any obstruction.
• Ensure the front & back air grills are not obstructed by your arms or any other object.
• Surface decontaminate any items including your arms or apparatus w/ an appropriate disinfectant before entering or exiting the work area.
• Place the waste container inside the cabinet work area place all items & apparatus in the safe working area.
• Minimize room activity personnel movements closing an opening of doors etc since these external airflow disturbances may adversely affect the cabinet's internal airflow. thereby possibly impairing the containment capabilities of the cabinet.
• Ensure that the sash is at a normal operating height before starting any experiment.
• Adjust the height of the lab chair so that the shoulder is approximately level w/ the front sliding sash to give you better visibility of the work zone & ensure that your face is protected by the front sash.

Working w/ a Cytoculture® Cytotoxic Safety Cabinet:
✔ Work as far inside the cabinet as possible at least 150 millimeters six inches behind the front air intake grille.
✔While working in the cabinet move your hands slowly & in a controlled manner. rapid movements may disrupt the air barrier allowing contaminants to escape or enter the cabinet.
✔ Minimize movement in the work zone across different areas.
✔ Leave the blower on for three minutes to purge airborne contamination from the work zone.

Turning off the cabinet:
✔ Turn off the fan by pressing the fan button; input the fan pin. This will also start the post purge procedure, during the post purge period all the buttons are not operational.
✔ Lower the sash to the fully closed position. The sash can be lowered
immediately after turning off the fan as it will not interrupt the post purge
procedure.
✔ Turn on the UV lamp when present to decontaminate the work area by pressing the UV button. The UV lamp can only be turned on after the post purge procedure is finished. leave the UV lamp on to make sure the decontamination is done effectively this can easily be done by setting the UV timer.

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For more information reach us at:
Website:
• Esco Pharma: http://www.escopharma.com/
• Esco TaPestle Rx: http://escotapestlerx.com/
• Esco Lifesciences: https://www.escolifesciences.com
LinkedIn: https://www.linkedin.com/company/esco-healthcare
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Esco Micro Pte. Ltd.
21 Changi South Street 1 Singapore 486777
Tel: +65 65420833
Fax: +65 65426920
Email: csis.pharma@escoglobal.com

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