18: How Stem Cells Work, Use in Brain Injury and the CCR5 Receptor l Stanley Carmichael MD, PhD

In this episode of the UCLA BrainSPORT Podcast, Adel discusses Stem Cells with the chair of the UCLA Department of Neurology and accomplished stem cell and brain injury research scientist, Dr. Stanley Carmichael. The two discuss what stem cells actually are, how they work and the evidence for their use in brain and spinal cord injury. They further discuss what utilizing stem cells to treat these injuries might look like in the future and current research directions. The pair then shift to discuss Dr. Carmichael's latest work, researching the blockade of the brain's CCR5 receptor. This has demonstrated great potential to enhance brain injury recovery, reverse the effects of dementia and even enhance healthy brain function.

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*This video is for informational purposes only and is not intended as a substitute or supplement for professional medical advice, consultation, or expertise. Please see a medical professional if you have any questions or concerns regarding any symptoms or injuries you have had.

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00:00 - Intro
5:12 - What are Stem Cells?
13:52 - Exosomes
17:53 - Evidence for Stem Cell Use in Brain Injury
25:24 - How do Stem Cells Work?
30:53 - Enhancing Stem Cell Survivability after Implantation
32:42 - Stem Cells for Spinal Cord Injury
34:29 - Tracking Stem Cell function with Optogenetics
37:08 - Longest Survival Time of a Stem Cell in the Brain
37:54 - fMRI to track Stem Cell Integration
39:15 - Stem Cell Migration to Injury
42:12 - Stem Cells and Neuroplasticity
43:54 - What would Stem Cell Implantation look like in practice?
46:15 - Stem Cells with Mutations?
47:19 - Best Timing for Stem Cell Implantation
49:40 - Potential Adverse Effects of Stem Cell Implantation
53:12 - Challenges to Stem Cell Therapy
58:25 - Future Direction of Research in Stem Cell Therapy
1:01:16 - The CCR5 Brain Receptor
1:03:34 - Evolutionary Function of the CCR5 Receptor
1:05:31 - CCR5 blockade enhances brain injury recovery
1:13:50 - The current drug that already blocks CCR5
1:15:12 - Can CCR5 blockade reverse effects of dementia?
1:16:36 - Enhancing learning and memory by blocking CCR5
1:19:08 - Potential adverse effects of CCR5 blockade
1:22:02 - Final words on Regenerative Medicine

Видео 18: How Stem Cells Work, Use in Brain Injury and the CCR5 Receptor l Stanley Carmichael MD, PhD канала UCLA Health