Virology Lectures 2016 #9: Reverse transcription and integration

Retroid viruses have the enzyme reverse transcriptase as part of their replication cycles. This enzyme, whose discovery by Temin and Baltimore shattered the dogma about the information flow in biological systems, produces DNA from RNA. In this lecture we discuss the discovery of reverse transcriptase in the context of RNA tumor viruses, the mechanism of reverse transcription and integration, and its role in the cycles of retroviruses and hepatitis B virus. We also consider the origin and functions of retroelements in the genome, mobile sequences that move about through the action of reverse transcriptase.

Видео Virology Lectures 2016 #9: Reverse transcription and integration канала Vincent Racaniello