Bovine Pituitary Extract BPE and Bovine Brain Extract BBE from Cell Applications & Hammond Cell Tech

“Bovine Pituitary Extract is a superior supplement for epithelial cells.”*

At Cell Applications, our Bovine Pituitary Extract and Bovine Brain Extract continue a decades-long legacy of pioneering work by Susan Hammond at the Dr. Richard Ham MCDB lab at the University of Colorado.

In 1984, Ms. Hammond established that Bovine Pituitary Extract or BPE supports epithelial cell growth while limiting fibroblast proliferation, enabling serum-reduced and in some systems, serum-free culture conditions.

This breakthrough enabled the long-term expansion and banking of human epithelial cells, making reproducible primary cell research practical and scalable.

Related work led to the development of Bovine Brain Extract (BBE), which supports endothelial and neuronal cell cultures.

In 1988, Ms. Hammond founded Hammond Cell Tech to standardize extraction methods for the global scientific community.

She optimized a non-lyophilized manufacturing process designed to preserve bioactivity and potency compared to generic, freeze-dried alternatives.

After 30 years, Ms. Hammond transferred these proprietary protocols exclusively to Cell Applications.

Today, Cell Applications remains the exclusive provider of Hammond method BPE and BBE, continuing the legacy of consistent performance and established cell culture standards.

Cell Applications quality controls BPE using human keratinocyte assays, and BPE is a core component across Cell Applications’ epithelial growth media, supporting airway, ocular, mammary, placental, renal, and urogenital cells, as well as melanocytes.

Visit www.cellapplications.com today to learn more about our high performance media and primary cells.

*Hammond SL, Ham RG, Stampfer MR. Serum-free growth of human mammary epithelial cells: rapid clonal growth in defined medium and extended serial passage with pituitary extract. Proc Natl Acad Sci U S A. 1984 Sep;81(17):5435-9. doi: 10.1073/pnas.81.17.5435. PMID: 6591199; PMCID: PMC391719.

Since 1994, Cell Applications, Incorporated has been the leader in primary cells. Our line of over 100 primary cells is complemented by a breadth cell biology products and custom services. CAI customers include cutting-edge pharmaceutical, drug discovery, biotechnology and consumer product companies, as well as leading universities and research institutes.

https://cellapplications.com/

Numerous publications cite the use of Cell Application products, and we are proud to be the primary cell provider for Dr. Shinya Yamanaka, awarded a 2012 Nobel Prize in stem cells. Time Magazine hailed his original 2007 paper as its medical breakthrough of that year.
With years of experience isolating, purifying, growing, and conducting experiments on primary cells, you can count on Cell Applications to provide expert technical support.

Located in San Diego, Cell Applications is a global company. We welcome the opportunity to energize your own cell culture research and game-changing discoveries.

Cell Applications, Inc
6455 Weathers Place
San Diego, CA 92121
800-645-0848 (US & Canada)
+1 (858) 453-0848
info@cellapplications.com

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