About Alphafold - An Awesome AI Invention That Will Change The Course of Medicine

Hear Tumblehome's AI expert Barnas talk/rant about how important the Alphafold 2 invention is, and why it's critical to the future of medicine. Learn about the science of genes vs proteins, and why the task of automating protein folding is complicated, but necessary to create vaccines and future cures for major medical issues like cancer. AI is solving today's biggest problems and it is important that more young students learn it and understand its power. Not just to learn how to use AI fix the world's problems, but how to use AI wisely and safely.

This is a general talk geared toward teachers who want to give real world examples of AI related science advances to their students, and/or more advanced high school students who have some exposure to biology or basic science concepts.

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Media Credits:

B-roll video and pictures from Pixabay.com

CASP Results Graph & Alphafold Architecture Diagram
Credit: Deepmind / Google

XRC Photo Credit
Kaspar Kallip - Own work
X-Ray crystallography is a tool used for identifying the atomic and molecular structure of a crystal. The movement of the machine during 80 second scan can give different view on how relatively slow scientific measurements can look frozen in time by shutter speed of 90 seconds.
CC BY-SA 4.0
File:Freezed XRD.jpg
Created: 30 November 2015
https://creativecommons.org/licenses/by-sa/4.0

Protein structure - Opabinia regalis -
Own work
CC BY-SA 4.0
File:1ppr peridinin chlorophyll protein.png
Created: 14 October 2016
About:
Crystal structure of the soluble peridinin-chlorophyll-protein complex from the photosynthetic dinoflagellate Amphidinium carterae. This complex is found in many photosynthetic dinoflagellates and involves a boat or cradle-shaped protein with two pseudosymmetrical repeats of eight alpha helices (shown in blue and orange) wrapped around a pigment-filled central cavity. Each eight-helix segment binds one chlorophyll molecule (green, with central magnesium ion shown as a green sphere), one diacylglycerol molecule (yellow) and four peridinin molecules (gray). Rendered using PyMol from PDB ID 1PPR. Hofmann E, Wrench PM, Sharples FP, Hiller RG, Welte W, Diederichs K. Structural basis of light harvesting by carotenoids: peridinin-chlorophyll-protein from Amphidinium carterae. Science. 1996;272(5269):1788-91. DOI 10.1126/science.272.5269.1788.
CCA License
https://creativecommons.org/licenses/by-sa/4.0

Diagram of DNA to Proteins:
English: Protein coding genes are transcribed to an mRNA intermediate, then translated to a functional protein. RNA-coding genes are transcribed to a functional non-coding RNA. (PDB: 3BSE​, 1OBB, 3TRA) Annotated version of not uploaded yet
Date 7 April 2015
Source Own work
Author Thomas Shafee
https://creativecommons.org/licenses/by-sa/4.0

Tertiary Structure of Proteins Diagram, Wikimedia Commons
Structure of the protein 1EFN, with focus on the tertiary structure.
Holger87 - Own work
CC BY-SA 3.0
File:Tertiary structure.png
Created: 27 August 2012
https://creativecommons.org/licenses/by-sa/4.0

Sickle Cell Anemia:
Diagram showing a part of the normal and mutated DNA strand, resulting change in mRNA and amino acid sequence.
Thomas Samuel for ACC-BioinnovationLab - Own work
CC BY-SA 4.0
File:Point-Mutation-Sickle-Cell-Normal and Mutated-Hemoglobin.png
Created: 22 July 2015

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