Improve Product Quality and Time to Market by Optimizing Time-Dependent Process Modeling

Multivariate analysis benefits and best practices for batch modeling and monitoring:
Variability of raw materials and intermediate products is a common problem in many industries, in particular in life sciences, and this remains a factor that must be accommodated in the various unit operations (process steps) to ensure a consistent product quality. In addition to variability of inputs, monitoring a batch process with several phases or varying duration is a key challenge for establishing model predictive control. Combining these challenges with the regulatory constraints, many organizations are experiencing strains on the effectiveness of product development and ultimately it is impacting time to market.

By using a multivariate approach we are able to monitor and model many parameters at the same time. Accordingly, the batch trajectories can be developed from advanced sensors such as spectrometers of different types to fully benefit from the resolution and sensitivity of these. By default the operational time in bioprocesses varies, and often there are different phases. Both in terms of mapping of the operational time to relative time and also for phase transitions this new batch modeling tool has proven effective. The method estimates the batch trajectory and confidence intervals in relative time and;

Removes dependence of the process time axis
Allows visualization of how the process evolves independent of sampling rate
Enables plot of individual variables in relative time
This innovative approach will provide new opportunities to improve quality, and serve to build greater confidence in the market for your products. We will share the most relevant cases where assumption-free modeling of time-dependent process has proven to substantially enhance early fault detection and thus improved process and product quality. Register for this webinar to gain insight in an innovative approach that will help you proactively address challenges in product development, in real-time manufacturing scenarios as well as in the quality control phase of the product.

Видео Improve Product Quality and Time to Market by Optimizing Time-Dependent Process Modeling канала Camo Analytics (Acquired by Aspen Technology)