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Adrenergic Drugs Part 2 | Pharmacology | Dr Najeeb

#drnajeeb #pharmacology #medicines #adrenergic #drugs # adrenergicdrugs

Adrenergic Drugs Part 2 | Pharmacology | Dr Najeeb

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▬▬▬▬▬▬▬▬▬▬ Contents of this video ▬▬▬▬▬▬▬▬▬▬
00:00:00 Characteristic physiological and pharmacological changes in body by stimulation of specific adrenoceptor
00:02:51 a) Alpha 1 Adrenergic Receptor
00:39:00 b) Alpha 2 Adrenergic Receptor
00:46:30 c) Beta 1 Adrenergic Receptor
01:09:16 d) Beta 2 Adrenergic Receptor
01:39:28 Intracellular signals, Molecular basis of Adrenergic Receptor
01:40:48 Intracellular signaling mechanism in Alpha 1 Adrenergic Receptor, seven pass receptors, serpentine receptors, Gq coupled protein receptors
01:56:45 Intracellular signaling mechanism in Alpha 2 Adrenergic Receptor, G inhibitory proteins
02:07:27 Intracellular signaling mechanism in Beta 1, Beta 2 and Beta 3 Adrenergic Receptor
02:14:48 Review
02:19:15 Desensitization
02:30:25 Rapid Desensitization
02:31:57 Homologous Desensitization
02:33:48 Heterologous Desensitization
02:40:45 Sequestration
02:47:48 Down regulation of receptor
02:48:35 Recap
02:57:50 Structure-Activity Relationship of sympathomimetic Amines
03:07:40 Direct acting sympathomimetic drugs
03:09:02 Indirect acting sympathomimetic drugs
03:10:30 Mixed action sympathomimetic drugs
03:12:30 Catecholamine, members of catecholamine and non-catecholamine
03:27:24 Recap
03:29:30 Different affinity of sympathomimetic drugs towards different Adrenergic Receptor
03:53:48 Recap

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Adrenergic Agonists are drugs that lead to stimulation of the adrenergic receptors. In doing so, adrenergic agonists generally simulate activation of certain aspects of the sympathetic nervous system and are thus also known as "sympathomimetics".

Mechanisms of Action

Overview

A diverse variety of sympathomimetics exist which operate using distinct mechanisms. In general, these compounds are divided into direct-acting, indirect-acting, or mixed-acting agonists depending on whether they directly activate adrenergic receptors or do so by indirect mechanisms

Direct-acting Agonists

Direct agonists physically bind the adrenergic receptor and simulate binding of an endogenous ligand. These compounds can be highly specific, activating only certain subtypes of receptors, or can be rather promiscuous.

Indirect-acting Agonists

Indirect agonists do not physically bind adrenergic receptors. Instead, these compounds indirectly lead to receptor activation through a variety of possible mechanisms which include promoting release of endogenously-stored norepinephrine from presynaptic terminals as well as inhibition of norepinephrine re-uptake and degradation from the synapse.

Mixed-acting Agonists

Mixed agonists simply refer to those compounds which display both direct and indirect mechanisms of actions. As such, these compounds directly bind adrenergic receptors but also promote the indirect mechanisms described above.
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2 апреля 2023 г. 17:00:10
03:56:09
Яндекс.Метрика