Chronic Kidney Disease Treatment - New CKD Drugs

Episode 266: Chronic Kidney Disease Treatment - New Game Changer Drugs to slow the progression of kidney disease and help you live longer. Dr. Rosansky discusses the latest on CKD treatment and the newest "game changer" medications. Dr. Rosansky, the author of Learn The Facts About Kidney Disease, makes understanding kidney disease and living with CKD much easier.

Main Discussion
1. Existing Treatments for Proteinuric Kidney Disease:
* ACE Inhibitors and ARBs: These drugs, around since 2001, are crucial for patients with significant proteinuria. They can slow kidney function decline and reduce the risk of needing dialysis by up to 50%.
* ACE Inhibitors: Drugs ending in "pril" (e.g., benazepril, enalapril, lisinopril).
* ARBs: Drugs ending in "tan" (e.g., losartan, valsartan, telmisartan).
2. Monitoring Proteinuria:
* Use urine dipsticks to measure protein levels. Consistent one-plus or more indicates significant proteinuria.
* Spot urine tests measuring albumin-to-creatinine ratio are also recommended.
3. New Game-Changer Drugs: SGLT2 Inhibitors:
* These drugs, initially designed for diabetics, have shown remarkable benefits in slowing kidney disease progression, reducing heart disease risk, and lowering the need for dialysis.
* Examples:
* Canagliflozin (Invokana)
* Dapagliflozin (Farxiga)
* Empagliflozin (Jardiance)
* Benefits include lowering blood pressure, aiding weight loss, reducing uric acid levels, and potentially lowering potassium levels.
4. Cost and Accessibility:
* SGLT2 inhibitors are expensive, around $300/month without insurance, but insurance can reduce the cost to about $50/month.
* Contacting drug manufacturers for discount programs can help reduce costs.
5. Potential Future Treatments: Mineralocorticoid Antagonists:
* Drugs like spironolactone and eplerenone may become part of treatment regimens, especially for those with high proteinuria. However, they need careful monitoring due to potential potassium increase.

Commonly used Angiotensin-converting enzyme inhibitor (ACE inhibitors) drugs include:
Benazepril (Lotensin), max 80 g
Captopril (Capoten), max 150 mg three times a day
Enalapril/ (Vasotec), 40 mg max
Fosinopril (Monopril), 80 mg max
Lisinopril (Zestril and Prinivil), 40 mg max
Quinapril (Accupril), 80 mg max
Ramipril (Altace), 20 mg max

Examples of angiotensin II receptor blockers (Arbs):
Candesartan (Atacand) 32 mg max
Irbesartan (Avapro) 300mg max
Losartan (Cozaar) 100 mg max
Olmesartan (Benicar) 40mg max
Telmisartan (Micardis) 80 mg max
Valsartan (Diovan) 320 mg max

SGLT2 Inhibitors:
Canagliflozin (Invokana®) 100-300mg/d
Dapagliflozin (Farxiga®) 5-10 mg/d
Empagliflozin (Jardiance®) 10-25 mg/d

Order the home test strips Dr. Rosansky recommends at: https://amzn.to/3SkINzU

Get Dr. Rosansky's helpful book "Learn The Facts About Kidney Disease" at http://go.dadvicetv.com/book

Dr. Rosansky is a highly respected nephrologist and an esteemed author of the book "Learn the Facts about Kidney Disease". With an illustrious career dedicated to the field of nephrology, he has made a significant impact on countless lives through his clinical practice and his insightful writing. His book has served as an essential guide for many patients navigating kidney disease, demystifying complex medical concepts and providing practical advice for managing the condition. Dr. Rosansky's commitment to patient education and his deep expertise in kidney health have firmly established him as a leading authority in the field of nephrology.
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IMPORTANT: This video is intended to be informational only. It is not a medical consultation, nor is it personalized medical advice. This video is not meant to replace a physician's advice, supervision, and counsel. For medical advice, please consult your physician.

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Видео Chronic Kidney Disease Treatment - New CKD Drugs канала Dadvice TV - Kidney Health Coach