How Did We Miss This Study?! (ft' Mike Mutzel)

For references and more information on this paper, see this letter: https://staycuriousmetabolism.substack.com/p/this-study-should-have-changed-medicineno?r=40ekz2

In part two of my interview with Mike Mutzel (from High Intensity Health channel), we dive into one of the most under-reported studies of 2024 — showing that statins can cut GLP-1 hormone levels in half. This matters because GLP-1 signaling isn’t just the target of blockbuster drugs like Ozempic and semaglutide, it’s a gut hormone tied to metabolic health, body composition, insulin resistance, and cardiovascular disease risk. If statins are lowering GLP-1 and contributing to worse glucose control and higher diabetes risk, why hasn’t this research made headlines?

Mike’s Channel (High Intensity Health): https://www.youtube.com/user/highintensityhealth

Prior Interview with Mike: https://youtu.be/bmU0ZSXZ1xg

GLP-1 Alzheimer’s Video: https://youtu.be/183PpRF4kgY

Statin’s Impact on Mitochondria: https://open.substack.com/pub/staycuriousmetabolism/p/the-mitochondrial-cost-of-statins?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

Chapters:
0:00 – Intro: Statins, GLP-1 & Metabolic Tug-of-War
0:45 – Statins Cut GLP-1 Levels by Half (Cell Metabolism Study)
1:30 – Why This Science Didn’t Make Headlines
2:47 – Statins, Insulin Resistance & Type 2 Diabetes Risk
3:44 – Drug Mechanisms: Thiazides, Beta Blockers & Side Effects
4:48 – Human Trial Data: Atorvastatin Worsens Glucose Control
5:29 – Doctors Unaware: Why Isn’t This Common Knowledge?
6:34 – Natural Ways to Boost GLP-1: Food, Exercise & Microbiome
7:06 – Microbiome, Bile Acids (UDCA/TUDCA) & GLP-1 Recovery
8:30 – UDCA Human Trial: HbA1c, Insulin & GLP-1 Improvements
9:12 – Coenzyme Q10, Statins & Mitochondrial Dysfunction
10:59 – JCI Insights: Statins Reduce Mitochondrial Capacity
11:48 – Risk-Benefit of Statins: Beyond Cholesterol
12:23 – Solutions: Monitoring HbA1c, Insulin & CGMs
13:13 – Why Medicine Changes Slowly & Patients Self-Experiment
14:01 – Confirmation Bias in Science & Reading Research
16:01 – Science, Bias & Industry Influence
18:00 – Future Biohacking Tools: Breath & Microbiome Monitoring
19:39 – Science as Democracy? Consensus vs Truth
22:30 – Being a Heretic in Science & Medical History Lessons
24:13 – Closing Thoughts & Where to Find Mike Mutzel

#Cardiovascularhealth #Cholesterol #GLP1 #UDCA #TUDCA #bileacids #hearthealth #heartdisease #atherosclerosis #educational #informative #medicaleducation #ApoB #LDL #HDL #highintensityhealth #insulin #insulinresistance #science #personalizedmedicine #statins #insulinresistance #type2diabetes #mitochondria #coq10 #metabolichealth #guthealth #microbiome #bileacids #healthscience #druginteractions #biohacking #healthoptimization #staycurious #informative #staycurious

Видео How Did We Miss This Study?! (ft' Mike Mutzel) канала Nick Norwitz