L 01 Introduction to protein X-ray Crystallography, significance and applications

🎓 Structural Biology Techniques and Its Role in Drug Discovery
📘 Course Code: 2441075
🏫 Offered by: GIAN and Banaras Hindu University, Varanasi
👨‍🏫 Course Coordinator: Prof. Pratyoosh Shukla
🌍 Foreign Faculty: Prof. Liang Tong

📌 What You’ll Learn (Topic-wise):
🧬 Lecture 1: Protein X-ray Crystallography – Applications & AlphaFold3

❄️ Lecture 2: Cryogenic Electron Microscopy (Cryo-EM) – 3D Reconstruction, CryoSPARC

💻 Tutorial 1: In Silico Protein Structure Tools – PyMOL, Coot, Python-based environments

🧫 Lecture 3: Open-source Molecular Graphics & Drug Discovery

🧠 Lecture 4: Protein Structures – Domains, Motifs, Folds

📐 Tutorial 2: Hands-on Protein Structure Prediction

🧪 Lecture 5: Fatty Acid Metabolism (Part I) – Catabolism & Binding Sites

🔄 Lecture 6: Fatty Acid Metabolism (Part II) – Allosteric Inhibitors, Catalysis

🔬 Tutorial 3: Protein Structure Analysis

🔗 Lecture 7: ATP-Citrate Lyase & Polyadenylation Signaling

🧷 Lecture 8: Protein Kinases & Proteases – Role in Drug Design

⚙️ Tutorial 4: Structure-Based Drug Target Analysis

💊 Lecture 9: Structural Biology in Drug Target Interactions – Kinases & Enzymes

🧫 Lecture 10: Case Studies – ACC, AMPK, ACLY, GPCRs in Drug Discovery

🧰 Tutorial 5: Software for Molecular Replacement, Alignment & Refinement

🔍 Keywords:
Structural biology, X-ray crystallography, cryo-EM, PyMOL, Coot, drug discovery, molecular graphics, protein kinases, ATP-citrate lyase, GPCR, AlphaFold3, bioinformatics tools, in silico modeling, enzyme structure, drug targets, BHU Varanasi

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Видео L 01 Introduction to protein X-ray Crystallography, significance and applications канала Global Initiative of Academic Networks - GIAN