Alternatives to animal testing

In toxicology, animal testing is still common. This video summarises a scientific paper by Gironde and co-authors [6] who used a human cell based method to predict human acute oral toxicity. Have a look at the video to find out which method is better, the animal test or the cell based method.

***Für deutsche Untertitel klickt im Video unten rechts auf das Rädchen!***
References

[1] European Commission (2019), REPORT FROM THE COMMISSION TO THE EUROPEAN PARLIAMENT AND THE COUNCIL 2019 report on the statistics on the use of animals for scientific purposes in the Member States of the European Union in 2015-2017, https://op.europa.eu/s/oApJ

[2] Hamm et al. (2017), Alternative approaches for identifying acute systemic toxicity: Moving from research to regulatory testing, https://doi.org/10.1016/j.tiv.2017.01.004
[3] Russell & Burch (1959), The principles of humane experimental technique, http://117.239.25.194:7000/jspui/bitstream/123456789/1342/1/PRILIMINERY%20%20AND%20%20CONTENTS.pdf
[4] European Commission (2009), Regulation (EC) No 1223/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products (L 342/59); http://data.europa.eu/eli/reg/2009/1223/oj
[5] OECD (2002), Guidance Document on Acute Oral Toxicity Testing, OECD Series on Testing and Assessment https://doi.org/10.1787/9789264078413-en.
[6] Gironde et al. (2020), Use of LUCS (Light-Up Cell System) as an alternative live cell method to predict human acute oral toxicity, https://doi.org/10.1016/j.toxrep.2020.02.010
[7] Derick et al. (2017), LUCS (Light-Up Cell System), a universal high throughput assay for homeostasis evaluation in live cells, https://doi.org/10.1038/s41598-017-18211-2
[8] Hoffmann et al. (2010), Acute oral toxicity: variability, reliability, relevance and interspecies comparison of rodent LD50 data from literature surveyed for the ACuteTox project, https://doi.org/10.1016/j.yrtph.2010.08.004

Видео Alternatives to animal testing канала Fantastic Studies and Where to Find Them