Introduction to PD -drug receptor interactions

Hi everyone,
I am back with 2 videos that will take you through the fundamentals of Pharmacodynamics.
As I have mentioned before, pharmacodynamics is really the study of how drugs produce their actions. As a simple concept, all drugs act by interacting specifically with its receptor. This drug-receptor binding kick starts a series of events, through various messenger chemicals to actuate a measurable biological response
We say that the drug interacts specifically with its receptor because each receptor only allows a very limited range of molecules to activate a response.
Specificity also refers to the fact that drug molecules can only activate a limited range of receptor types. Now some drug receptor interactions are highly specific, while others are less so. But we won’t bother with that now.
When a drug molecule initiates a response, that molecule is called an agonist. Not all drugs however, are agonists. Some drugs act by binding to a receptor and preventing an endogenous physiological agonist from producing its physiological effect. Such drugs are called antagonists.
So far we have beentalking about drug-receptor generated responses as being reversible, but not all drug responses are reversible. Many responses can be irreversible. For example, omeprazole is an irreversible inhibitor of the proton pump.
Many oncologicals are irreversible because they cause destruction of cancer cells.
Some drugs on the other hand, can stimulate cell growth.
As you can see drugs can produce a biological response through a wide variety of mechanisms. We cannot cover everything here. What they all share in common is the very specifici nature of the interaction between the drug molecule and its biological “receptor” which may come in various forms.
We will stop here for the moment, but don’t go away, because we will continue this presentation by looking at the concentration response relationship.
I’ll see you then.

Видео Introduction to PD -drug receptor interactions канала pharmacology tutorials