Perspective on autoimmunity: a view from the ANCA vasculitis looking glass

Perspective on autoimmunity: a view from the ANCA vasculitis looking glass

Air date: Wednesday, November 2, 2016, 3:00:00 PM

Category: WALS - Wednesday Afternoon Lectures

Runtime: 00:59:24

Description: NIH Director's Wednesday Afternoon Lecture

Astute Clinician Lecture

Dr. Falk's research probes questions focused on immune-mediated kidney diseases, especially glomerulonephritis. His clinical and basic science interests include both anti-neutrophil cytoplasmic autoantibody (ANCA) glomerulonephritis and small vessel vasculitis (SVV). A central objective of Falk's research is elucidating the causes of ANCA necrotizing and crescentic glomerulonephritis. Unraveling the cause of this disease requires considering a number of factors involved in the development of ANCA glomerulonephritis. Dr. Falk conceptualizes this process as opening the vasculitis lock with a key that has a number of "ridges and valleys" analogous to those factors that contribute to the development of this autoimmune disease. Dr. Falk participates in a research group that, in a large study over the last four years, has revealed a number of avenues of investigation and new approaches to ongoing questions that pertain not only to ANCA glomerulonephritis, but to the general fields of autoimmunity, inflammation and basic neutrophil and monocyte biology.

This annual lecture started in 1998 and honors a U.S. scientist who has observed an unusual occurrence, and by investigating it, has opened an important new avenue of research. The lectureship exemplifies how astute clinical observations can lead to innovative research. Speakers are selected by the NIH Clinical Center.

For more information go to https://oir.nih.gov/wals/2016-2017
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Author: Ronald J. Falk, M.D., Hugh and Nan Cullman Eminent Professor and Chair, Department of Medicine at University of North Carolina - Chapel Hill

Permanent link: https://videocast.nih.gov/launch.asp?19984

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