Seminar: Oxidative stress and atrial fibrillation (Prof. Barbara Casadei)

Watch the presentation on Slideshare: http://www.slideshare.net/VHIR/barbara-casadei

"Oxidative stress and atrial fibrillation: a long journey in to the clinic?"

VHIR Seminar led by Professor Barbara Casadei MD DPhil FRCP. British Heart Foundation Professor of Cardiovascular Medicine L6 West Wing - John Radcliffe Hospital University of Oxford.

Content: Atrial fibrillation (AF) is the most common clinical arrhythmia and is associated with significant morbidity and increased mortality. To date, the mechanisms responsible for the new onset of AF are only partially understood and even less is known of the processes that underlie the progression from paroxysmal to persistent AF and influence the response to treatment. In the absence of therapeutic approaches targeting the signalling pathways involved in the substrate that supports AF, current management is mainly focussed on relieving symptoms and preventing embolic stroke. There is therefore a pressing need to deepen our understanding of the pathogenesis of AF and identify mechanisms that could be targeted by novel therapeutic interventions. Our work has shown that atrial NOX2 activity is an independent predictor of post-operative AF in patients undergoing cardiac surgery and that short-term statin therapy or ex-vivo incubation inhibits myocardial NOX2 activityin humans and suppresses AF induction in a mouse model of myocardial specific NOX2 overexpression. The impact of atrial NOX2 inhibition by statins on post-operative AF and perioperative irreversible myocardial damage is now being tested in a large randomised clinical trial (STatinsIn Cardiac Surgery (STICS), http://www.clinicaltrials.gov).

Видео Seminar: Oxidative stress and atrial fibrillation (Prof. Barbara Casadei) канала Vall d'Hebron Barcelona Hospital Campus