Bilirubin metabolism ( Heme catabolism) by Dr Rajesh Jambhulkar

Heme catabolism
Heme degradation in macrophages
Bilirubin transport with albumin
Bilirubin metabolism
1. Uptake by hepatocytes by facilitated diffusion
2. Conjugation of unconjugated bilirubin
3. Secretion in to bile canaliculi by active transport through MRP 2

Congenital causes
UNCONJUGATED BILIRUBIN INCREASE
1. Crigler Najjar type 1
2. Crigler Najjar type 2
3. Gilbert syndrome

Conjugated bilirubin increase
1. Dubin Johnson syndrome
2. Rotor syndrome
Books
Harper's illustrated Biochemistry 31st

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