Nerve Hijack in Leprosy | Peripheral Nerve Involvement Explained | MD Dermatology

Why does Mycobacterium leprae selectively target peripheral nerves? Learn the complete mechanism of nerve involvement in leprosy, including Schwann cell invasion, nerve examination, disability assessment, and practical examination pearls.
Leprosy is unique among infectious diseases because of its remarkable affinity for peripheral nerves. But how does Mycobacterium leprae hijack the nervous system?

In this lecture, we explore the complete spectrum of nerve involvement in leprosy, from pathogenesis and nerve tropism to clinical examination, nerve function assessment, and practical examination pearls.

Topics Covered:

• Why does M. leprae affect nerves?

• Schwann Cell Invasion

• Mechanism of Nerve Damage

• Immunological Basis of Neuropathy

• Ulnar Nerve Involvement

• Median Nerve Involvement

• Radial Cutaneous Nerve

• Common Peroneal Nerve

• Posterior Tibial Nerve

• Greater Auricular Nerve

• Facial Nerve Involvement

• Pure Neuritic Leprosy

• Thickened Nerves in Leprosy

• Sensory Examination

• Voluntary Muscle Testing (VMT)

• WHO Disability Assessment

• Monofilament Testing

• Nerve Function Impairment

• Red Flag Signs of Neuritis

• Practical Examination Approach

• MD Dermatology Viva Questions

• Examiner's Favorite Topics

• NEET PG & INICET High-Yield Points

This lecture is ideal for MD Dermatology residents, DNB residents, postgraduate practical examinations, viva preparation, and clinicians interested in Hansen's disease.

Part of the LEPROSY MONTH 2026 Masterclass Series.

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