Validation of patient derived xenograft (PDX) models - PeerJ Video Abstract

PeerJ Video Abstract for 'A systematic review of the validity of patient derived xenograft (PDX) models: the implications for translational research and personalised medicine' by Anne T Collins and Shona H Lang https://peerj.com/articles/5981/

Patient-derived xenograft (PDX) models are increasingly been used in oncology drug development because they offer greater predictive value than traditional cell line models. Using novel tools to critique model validity and reliability we performed a systematic review to identify all original publications describing the derivation of PDX models of colon, prostate, breast and lung cancer. Validity was defined as the ability to recapitulate the disease of interest. The study protocol was registered with the Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies (CAMARADES), http://www.dcn.ed.ac.uk/camarades/default.html

Collins AT, Lang SH. 2018. A systematic review of the validity of patient derived xenograft (PDX) models: the implications for translational research and personalised medicine. PeerJ 6:e5981 https://doi.org/10.7717/peerj.5981

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