Study Shows How Antioxidants May Undo High Fat Diet Damage

#highfatdiet #antioxidants #molecularcell

A new study published in Molecular Cell sheds light on how high-fat diets disrupt cellular metabolism and increase the risk of metabolic diseases. Conducted by researchers at the Massachusetts Institute of Technology (MIT), the study reveals that many of the damaging effects of a high-fat diet can be reversed by the use of antioxidants. The research, led by Tigist Tamir, now a professor at the University of North Carolina, and senior author Forest White of MIT, explores the biochemical disruptions at the cellular level that lead to weight gain and insulin resistance.
Consuming a high-fat diet is already linked to obesity, diabetes, and chronic disease, but the molecular mechanisms behind these risks have remained unclear. To investigate, the researchers used a mouse model to observe the effects of a high-fat diet over time, particularly focusing on how it alters enzyme activity in metabolic pathways. They discovered that hundreds of enzymes involved in sugar, lipid, and protein metabolism became dysregulated through a process called phosphorylation, where enzymes are turned on or off in response to stress or nutrient levels.
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Видео Study Shows How Antioxidants May Undo High Fat Diet Damage канала Medical Dialogues