Clinical Trial Shows Diabetes Drug May Help Treat Liver Inflammation

#diabetesdrug #dapagliflozin #fattyliverdisease

A new study found that dapagliflozin, a sodium glucose cotransporter 2 (SGLT-2) inhibitor, improved key liver conditions associated with metabolic dysfunction-associated steatohepatitis (MASH) and fibrosis according to a new clinical trial published in The BMJ.
MASH is a form of non-alcoholic fatty liver disease (NAFLD) characterized by the accumulation of fat in the liver, leading to inflammation and, in many cases, scarring or fibrosis. It is considered a major global health concern, with few effective pharmacological treatments currently available.
To evaluate the impact of dapagliflozin on MASH, researchers enrolled 154 adults across six medical centers in China between November 2018 and March 2023. Participants had all been diagnosed with MASH following a liver biopsy. Nearly half had type 2 diabetes, and almost all had evidence of liver fibrosis.
Patients were randomly assigned to receive either 10 mg of dapagliflozin or a placebo once daily for 48 weeks. They also attended biannual health education sessions and underwent regular assessments of liver enzymes, blood glucose, insulin, lipid profiles, and other metabolic markers.

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