What is Gain-of-Function research? Evolutionary question #23

Below are all the links you will need to do a deep dive into this terrifying topic... I hope you enjoy reading over 1000 pages of dooms-day horror mixed with legal and scientific jargon as I did!

My highlighted copy of the White-Paper: Gain-of-Function research ethical analysis:
https://drive.google.com/file/d/1PpyLox-YAwdzsce-cOqGErFhMORPupWk/view?usp=sharing

NIH Definition of GoF research and resource links
https://osp.od.nih.gov/biotechnology/gain-of-function-research/

List of Select Agents. Research with these pathogens/toxins is strictly regulated by the US federal government.
https://www.selectagents.gov/sat/list.htm

2014 Pause on GoF research funding
https://www.phe.gov/s3/dualuse/Documents/gain-of-function.pdf

2014 GoF Government Workshop
https://www.nap.edu/download/21666

Risk and Benefit Analysis by Federal Government, 2016
http://gryphonsci.wpengine.com/wp-content/uploads/2018/12/Risk-and-Benefit-Analysis-of-Gain-of-Function-Research-Final-Report-1.pdf

Recommendations for Evaluation and Oversight of Proposed GoF Research, 2016
https://osp.od.nih.gov/wp-content/uploads/2016/06/NSABB_Final_Report_Recommendations_Evaluation_Oversight_Proposed_Gain_of_Function_Research.pdf

Review Requirements for GoF research, 2017
https://www.phe.gov/s3/dualuse/Documents/p3co.pdf

Lift of GoF Funding Freeze by Federal Government
https://www.nih.gov/about-nih/who-we-are/nih-director/statements/nih-lifts-funding-pause-gain-function-research

List of Current GoF projects funded by US agencies
https://www.phe.gov/s3/dualuse/Pages/Two-Research-Projects-PPP.aspx

00:00 Introduction
00:47 Sources of information for this presentation
02:17 Audience questions about Gain of Function research
03:33 First controversial virology experiment
05:27 Factory Farming and virus evolution
08:06 Origin of the 1918 Spanish Flu
09:30 Publication of the first dangerous Gain of Function experiment H5N1
12:25 Dr. Fauci supports the work but gives word of caution on Gain of Function experiments
13:24 Dr. David Relman warns that certain types of Gain of Function research is unethical
14:18 Controversial Gain of Function research continues in US labs, early 2014
16:02 Three US Lab accidents trigger halt on GoF Research, late 2014
18:46 Gain of Function defined, as it applies to the research ban
19:46 Purpose of Gain of Function research
22:47 How does Gain of Function research work?
28:08 Risks of Gain of Function research
32:10 Safer Alternatives
34:10 Gain of Function research started again in 2017 with new guidelines
35:15 Jon Perry's thoughts on all of this

Видео What is Gain-of-Function research? Evolutionary question #23 канала Jon Perry - Genetics & Evolution Stated Casually