Generational Trauma as Inherited Priors — Active Inference E06 | IamHITL

Generational trauma is not a metaphor. It is, increasingly, a measurable signal in the next generation — and Active Inference gives us the formal lens to read it.

Episode 6 of a 20-video series on Active Inference (Friston, Parr, Pezzulo) and the trauma loops it diagnoses across society.

What this episode covers:
• Yehuda et al. 2016 — first demonstration in humans of an ASSOCIATION between preconception parental trauma and inherited epigenetic alterations (FKBP5 methylation in Holocaust survivors + offspring)
• Heijmans et al. 2008 — IGF2 methylation differences in Dutch Hunger Winter exposed individuals six decades after prenatal famine
• The Active Inference reframing: prior preferences (the "C matrix") encode what outcomes a system expects to find. Inherited priors → policies the next generation never chose

Important framing: Yehuda is cited as "first demonstration of an ASSOCIATION" — not as causal proof. Mechanism debate continues. We use Active Inference as a theoretical lens that organizes the evidence, not a closed mechanistic explanation.

Citations:
• Yehuda, R., Daskalakis, N.P., Bierer, L.M., Bader, H.N., Klengel, T., Holsboer, F., Binder, E.B. (2016). "Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation." Biological Psychiatry 80(5):372-380. https://scholars.mssm.edu/en/publications/holocaust-exposure-induced-intergenerational-effects-on-fkbp5-met-2/
• Heijmans, B.T. et al. (2008). "Persistent epigenetic differences associated with prenatal exposure to famine in humans." PNAS 105(44):17046-17049. https://ui.adsabs.harvard.edu/abs/2008PNAS..10517046H/abstract
• Smith, R., Friston, K.J., Whyte, C.J. (2022). "A step-by-step tutorial on active inference and its application to empirical data." Journal of Mathematical Psychology 107:102632. https://discovery.ucl.ac.uk/id/eprint/10143770/

ORCHESTRATE Method — IamHITL.

Видео Generational Trauma as Inherited Priors — Active Inference E06 | IamHITL канала ORCHESTRATE Master