Lecture 11 Transposable Elements | Cut-and-Paste, Retrotransposons, Immune Diversity

In this Molecular Biology lecture, we explore the fascinating world of transposable elements (TEs)—mobile DNA sequences that move within and between genomes. From bacterial IS elements to eukaryotic retrotransposons, this video explains their structure, function, and evolutionary relevance.

Topics Covered:
What are transposable elements (TEs)?
Bacterial TEs:
Insertion sequences (IS1), composite transposons (Tn5, Tn10)
Mechanisms: Cut-and-paste vs. replicative transposition (Tn3)
Hairpin transposition and hemimethylation-based timing
TE applications in biotechnology and genetics

Eukaryotic TEs:
Class I (RNA-mediated): LTR & Non-LTR retrotransposons (LINEs, SINEs)
Class II (DNA-only): hAT elements, Sleeping Beauty
Transposons in immunology:
V(D)J recombination in B-cells and T-cells
RAG1/2 enzymes and immune gene diversity
Similarities between retrotransposons and retroviruses
Applications in functional genomics and gene discovery

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Видео Lecture 11 Transposable Elements | Cut-and-Paste, Retrotransposons, Immune Diversity канала Professor Givon's Lectures