Chloroquine, Hydroxychloroquine & SARS-CoV-2 (COVID-19): Mechanism & Overview of Anti-Viral Effects

Chloroquine, Hydroxychloroquine & SARS-CoV-2 (COVID-19) | Mechanism of Action and Overview of Anti-Viral Properties

****UPDATE (April 24th, 2020): The FDA has issued a WARNING AGAINST THE USE OF CHLOROQUINE/HYDROXYCHLOROQUINE for COVID-19 due to SIGNIFICANT CARDIAC SIDE EFFECTS****

This is a follow-up lesson to my previous Chloroquine & Hydroxychloroquine video. As some commenters noted (thanks to Zhijie Wang and The123michaelsilva), I neglected to discuss the anti-viral mechanism against SARS-CoV-2 (novel coronavirus) in enough detail and missed important points regarding mechanism of action. In this lesson, I discuss these multiple anti-viral mechanisms in more detail including the ability of chloroquine/hydroxychloroquine to inhibit endocytosis, act as a zinc ionophore and a novel mechanism (recently discovered in April 2020) wherein chloroquine/hydroxychloroquine affect viral binding.

*Re-uploaded due to error in previous version*

1) Brief Introduction to Multiple Mechanisms of Action of Chloroquine/Hydroxychloroquine

2) Chloroquine/Hydroxychloroquine inhibits viral endocytosis

3) Chloroquine acts as zinc ionophore

4) Chloroquine/Hydroxychloroquine interfere with viral binding

*DISCLAIMER* All of these mechanisms have ONLY been shown in in-vitro studies (in a cell culture plate), so these mechanisms MAY NOT translate to actual clinical significance in treating humans. Until we have data from a randomized controlled trial in humans, WE DON’T KNOW whether these medications have anti-viral treatment properties (against SARS-CoV-2) in humans or not! This lesson is for information purposes ONLY. Please DO NOT take these medications without consulting a physician. These medications can have SEVERE (and possibly fatal) effects.

****EXCLAIMER: The content (ex. images) used in this lesson are used in accordance with Fair Use laws and is intended for educational purposes only.****

***This video is merely here to PRESENT INFORMATION from the studies quoted in this video - if people have an issue with the data, I would suggest they read over these studies and contact the experimenters/authors of these articles instead of leaving accusatory and inflammatory comments in this comment section****

I hope you find this lesson helpful! If you do, please give this video a thumbs up and consider subscribing to the channel – all of your support is greatly appreciated!

JJ

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Check out some of my other lessons.

Infectious Disease Playlist
https://www.youtube.com/playlist?list=PLRjNoiRtdFwW0Bkc6c66uDACkzotaK26b

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Pharmacology Playlist
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Hematology Playlist
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Rheumatology Playlist
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Endocrinology Playlist
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Nephrology Playlist
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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.

Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.

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*Although I try my best to present accurate information, there may be mistakes in this video. If you see any mistakes, please let me know :) *

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