Mechanism of action of Spironolactone

● Diuretics Pharmacology:
• Loop Diuretics Mechanism of Action: https://youtu.be/fWD4AipDsUs
• How Loop Diuretics Cause Hypocalcemia: https://youtu.be/XhqY2xFrKAo
• Thiazides Mechanism of Action: https://youtu.be/RDMJiK-GYRU
• How Diuretics Cause Hypokalemia: https://youtu.be/6HbPdemPZU0

● Cardiovascular System Pharmacology:
• Digoxin - Mechanism of Action: https://youtu.be/N1hOpbg3fXw
• ACE Inhibitors (Angiotensin Converting Enzyme Inhibitors): https://youtu.be/yq0cMaaOtAc
• Angiotensin Receptor Blockers (ARBs): https://youtu.be/WxHTwBYdpFg
• Direct Renin Inhibitors (Aliskiren): https://youtu.be/7jzvHj4PTh8
• Nitrates | Mind Map: https://youtu.be/K5qvErQqwgM
• Calcium Channel Blockers | Mind Map: https://youtu.be/U3drMV4cvu0

This video describes mechanism of action of spironolactone. It's an aldosterone antagonist. Aldosterone regulates Na reabsorption by principle cells at collecting duct. It increases synthesis as well as activity of Na-K ATPase pump and epithelial Na channels which plays important role in Na reabsorption at collecting duct. Due their increased activity Na reabsorption is increased. Increased Na reabsorption indirectly increases K excretion. Spironolactone inhibits mineralocorticoid receptors through which aldosterone exerts it's effect. So all the effects of aldosterone is decreased. Na is lost in urine and K is prevent from excretion.

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DISCLAIMER: This video is for education purpose only. Although every effort is made to ensure accuracy of material, viewer should refer to the appropriate regulatory body/authorised websites, guidelines and other suitable sources of information as deemed relevant and applicable. In view of possibility of human error or changes in medical science, any person or organization involved in preparation of this work accepts no responsibility for any errors or omissions or results obtained from use of information in this video.

Видео Mechanism of action of Spironolactone канала Nonstop Neuron