CSIR NET Life Science PYQ 2025 | DNA Replication Trick Question

🧬 Molecular Biology MCQ Explained
Question:
Which one of the following enzymes can unwind short stretches of DNA helix immediately ahead of a replication fork?
Helicase
Topoisomerase ✅
DNA polymerase
DNA gyrase
Explanation:
During DNA replication, helicase separates DNA strands, creating supercoiling tension ahead of the replication fork.
Topoisomerase relieves this stress by cutting and rejoining DNA strands, helping the DNA unwind properly.
✔ Helicase → unwinds DNA at the replication fork
✔ Topoisomerase → relieves supercoiling ahead of the fork
✔ DNA polymerase → synthesizes DNA
✔ DNA gyrase → bacterial topoisomerase
📚 Useful for:
CSIR NET Life Science
DBT JRF
GAT-B
CUET PG Biotechnology
MSc Biotechnology Entrance
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Видео CSIR NET Life Science PYQ 2025 | DNA Replication Trick Question канала The Hidden Biologist