WEBINAR CEA: METABOLIC PATHWAY ANALYSIS AND DYNAMIC MODEL DERIVATION
05 MAYO 2022 - 18.00H A 19.00H
METABOLIC PATHWAY ANALYSIS AND DYNAMIC MODEL DERIVATION
Summary
The notion of elementary flux mode (EFM) is a key concept derived from the analysis of metabolic networks from a pathway-oriented perspective. The EFMs are the shortest pathways through a metabolic reaction network that connect external substrates to products.
The EFM computation can be used for different purposes, including the determination of the distribution of fluxes in a metabolic network under the constraints provided by the network stoichiometry and the measurements of extracellular fluxes, as well as the derivation of dynamic macroscopic models.
The former problem is generally underdeterminate and the set of solution is a pointed polyhedral cone, so that the flux distribution can only be provided in the form of intervals. The latter problem is concerned with the consideration of a reduced set of EFMs, the determination of a macroscopic bioreaction scheme and its associated kinetics. This presentation reviews the key concepts and presents a few applications.
Speaker
ALAIN VANDE WOUWER GRADUATED IN ELECTRICAL ENGINEERING FROM THE FACULTÉ POLYTECHNIQUE DE MONS (BELGIUM) IN 1988, AND OBTAINED A PHD IN APPLIED SCIENCES FROM THE SAME UNIVERSITY (IN COLLABORATION WITH STUTTGART UNIVERSITY FOR A EUROPEAN DOCTORATE DEGREE) IN 1994. THIS LATTER YEAR, HE ALSO ACHIEVED A POSTDOCTORAL STAY IN THE MECHANICAL ENGINEERING DEPARTMENT OF UNIVERSITÉ LAVAL (QUEBEC).
SINCE THEN, HE HAS BEEN WORKING AT THE UNIVERSITY OF MONS, WHERE HE IS CURRENTLY THE HEAD OF THE SYSTEMS, ESTIMATION, CONTROL AND OPTIMIZATION GROUP.
FOR THE LAST 20 YEARS, HE HAS FOCUSED MOST OF HIS RESEARCH ON BIOPROCESS MODELING, ESTIMATION AND CONTROL, DEVELOPING COLLABORATIONS WITH INDUSTRIES AND INTERNATIONAL RESEARCH GROUPS, AND PARTICIPATING IN SEVERAL RESEARCH PROJECTS. IN RECENT YEARS, HE ALSO ENGAGED IN RESEARCH ON FLIGHT CONTROL OF UNMANNED AERIAL VEHICLES.
Видео WEBINAR CEA: METABOLIC PATHWAY ANALYSIS AND DYNAMIC MODEL DERIVATION канала CEAUTOMATICA Comité Español de Automática
METABOLIC PATHWAY ANALYSIS AND DYNAMIC MODEL DERIVATION
Summary
The notion of elementary flux mode (EFM) is a key concept derived from the analysis of metabolic networks from a pathway-oriented perspective. The EFMs are the shortest pathways through a metabolic reaction network that connect external substrates to products.
The EFM computation can be used for different purposes, including the determination of the distribution of fluxes in a metabolic network under the constraints provided by the network stoichiometry and the measurements of extracellular fluxes, as well as the derivation of dynamic macroscopic models.
The former problem is generally underdeterminate and the set of solution is a pointed polyhedral cone, so that the flux distribution can only be provided in the form of intervals. The latter problem is concerned with the consideration of a reduced set of EFMs, the determination of a macroscopic bioreaction scheme and its associated kinetics. This presentation reviews the key concepts and presents a few applications.
Speaker
ALAIN VANDE WOUWER GRADUATED IN ELECTRICAL ENGINEERING FROM THE FACULTÉ POLYTECHNIQUE DE MONS (BELGIUM) IN 1988, AND OBTAINED A PHD IN APPLIED SCIENCES FROM THE SAME UNIVERSITY (IN COLLABORATION WITH STUTTGART UNIVERSITY FOR A EUROPEAN DOCTORATE DEGREE) IN 1994. THIS LATTER YEAR, HE ALSO ACHIEVED A POSTDOCTORAL STAY IN THE MECHANICAL ENGINEERING DEPARTMENT OF UNIVERSITÉ LAVAL (QUEBEC).
SINCE THEN, HE HAS BEEN WORKING AT THE UNIVERSITY OF MONS, WHERE HE IS CURRENTLY THE HEAD OF THE SYSTEMS, ESTIMATION, CONTROL AND OPTIMIZATION GROUP.
FOR THE LAST 20 YEARS, HE HAS FOCUSED MOST OF HIS RESEARCH ON BIOPROCESS MODELING, ESTIMATION AND CONTROL, DEVELOPING COLLABORATIONS WITH INDUSTRIES AND INTERNATIONAL RESEARCH GROUPS, AND PARTICIPATING IN SEVERAL RESEARCH PROJECTS. IN RECENT YEARS, HE ALSO ENGAGED IN RESEARCH ON FLIGHT CONTROL OF UNMANNED AERIAL VEHICLES.
Видео WEBINAR CEA: METABOLIC PATHWAY ANALYSIS AND DYNAMIC MODEL DERIVATION канала CEAUTOMATICA Comité Español de Automática
Показать
Комментарии отсутствуют
Информация о видео
17 июня 2022 г. 19:49:15
01:15:39
Другие видео канала
