Guide RNA dependent RNA editing

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RNA editing is a molecular process through which some cells can make discrete changes to specific nucleotide sequences within a RNA molecule after it has been generated by RNA polymerase. RNA editing is relatively rare, and common forms of RNA processing (e.g. splicing, 5'-capping and 3'-polyadenylation) are not usually included as editing. Editing events may include the insertion, deletion, and base substitution of nucleotides within the edited RNA molecule.

RNA editing has been observed in some tRNA, rRNA, mRNA or miRNA molecules of eukaryotes and their viruses, archaea and prokaryotes.[1] RNA editing occurs in the cell nucleus and cytosol, as well as within mitochondria and plastids. In vertebrates, editing is rare and usually consists of a small number of changes to the sequence of affected molecules. In other organisms, extensive editing (pan-editing) can occur; in some cases the majority of nucleotides in a mRNA sequence may result from editing.

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