Mitochondrial Mutations in Aging - Dr. Aubrey de Grey
In this video, SRF Chief Science Officer Dr. Aubrey de Grey discusses mitochondrial mutations, their role in aging, and the SENS approach to combatting their deleterious effects. Dr. de Grey opens his lecture by describing the structure of mitochondrial DNA (mtDNA) in humans. In particular, he explains that only thirteen protein-encoding mitochondrial genes actually reside in mitochondria. Throughout the course of human evolution, over a thousand other mitochondrial genes have migrated to the nuclear genome. Next, he explains the major theories developed between the 1970 and the present that aimed to explain the role of mtDNA mutations in aging. During his discussion of the most recent theoretical ground, Dr. de Grey explains his own contribution to the field: an alternative hypothesis to explain how clonal expansion of mutant mitochondria might occur. He then turns to therapeutic strategies and discusses the three main mechanisms by which scientists might intervene in mitochondrial aging. Dr. de Grey closes by describing the mechanism SRF finds most promising: inserting the thirteen protein-encoding mitochondrial genes into the nucleus modified in such a way that the corresponding RNA transcripts or protein-products can be imported into the mitochondria.
Visit www.sens.org/videos to view the rest of our course lecture videos.
Видео Mitochondrial Mutations in Aging - Dr. Aubrey de Grey канала SENS Foundation
Visit www.sens.org/videos to view the rest of our course lecture videos.
Видео Mitochondrial Mutations in Aging - Dr. Aubrey de Grey канала SENS Foundation
Показать
Комментарии отсутствуют
Информация о видео
Другие видео канала
The Role of Mitochondria in Aging and Disease - David SinclairA Real-Life Mutant: Meet The Woman Who Feels No Pain | Mach | NBC NewsA Mitochondrial Etiology of Common Complex DiseasesHow Two Microbes Changed HistoryDavid Sinclair - Cracking & reversing the aging clock - Frontiers Forum 2019MitoSENS - Preventing Mitochondrial AgingThe Hallmarks of Aging: Mitochondrial dysfunction | LifeXtenShow5 most promising anti-aging compounds (for 2021)Rejuvenation Biotechnology: Why Age May Soon Cease To mean Aging; Aubrey de Grey, CSO at SENSMitochondrial Dysfunction and Telomere Attrition – Aging | LecturioYou Can Inherit Mitochondrial DNA from Both Parents! | SciShow NewsMitochondrial Protector: AMPKExercise training prescription to maximise improvements in mitochondria function and content?How do mitochondria contribute to health and disease? - Peter McGuireMitochondrial BehaviorWhy We Age - And How We Can Stop ItMitochondrial Energetics and Insulin Resistance of AgingThe Judgment Call Podcast Episode #58 – Aubrey de Grey (Can we finally reverse aging 'forever'?!)Mitochondria: Functions, Genomics and DiseaseMitochondria, Aging, and Health