Low-Dose mRNA-1273 COVID-19 Vaccine Generates Durable Memory Enhanced by Cross-reactive T Cells

Presented By: Daniela Weiskopf, PhD

Speaker Biography: I have devoted my career understanding the T cell response to viral pathogens and spent the last sixteen years studying infectious viruses relevant to human health and disease. In 2009, I received my PhD in Immunology from Innsbruck Medical University, Austria, where I performed research analyzing posttranslational modifications of virus-derived epitopes and modulation of the T cell immune response during aging. Following my PhD, I obtained post-doctoral training at the La Jolla Institute for Immunology (LJI) where my efforts were dedicated to characterize human dengue virus-specific CD8+ and CD4+ T cell responses in samples from areas with endemic dengue infection and following experimental dengue vaccination. One important outcome of these studies was the development of dengue specific epitope megapools (MPs) that allow the testing of virus specific T cells in small amounts of blood irrespective of HLA restriction of the donor and infecting serotype. I have further expanded my repertoire to study Zika and Chikungunya virus specific T cell responses and also became interested in the effects of pre-existing immunity against dengue virus to subsequent zika virus infection.

Webinar: Low-Dose mRNA-1273 COVID-19 Vaccine Generates Durable Memory Enhanced by Cross-reactive T Cells

Webinar Abstract: Vaccination and infection are two different paths to immunity. Understanding human immune responses to SARS-CoV-2 RNA vaccines is of interest for a panoply of reasons. mRNA vaccines have demonstrated impressive protection from COVID-19; however, durability of immunity has been a major unknown.

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