The Role of MCAS in Long Covid | With World Leading Specialist Dr Lawrence Afrin

The biological mechanisms of Long Covid are still somewhat of a mystery. But as we dig into the jigsaw looking for the pieces, one of the largest we've found is Mast Cell Activation Syndrome.

In this wide ranging interview with one of the world's leading specialists in the field, Dr Lawrence Afrin, he sheds light on the presentation, pathophysiology and treatment of the condition, as well as its complexity.

A huge thank you to Dr Afrin for his time, knowledge and wisdom.

Wondering who I am and why I'm making these films? I talk about it here:
https://www.youtube.com/watch?v=FULycGPmN18

0:00 Introduction
0:44 What are mast cells?
1:34 What role do mast cells play in the body?
3:12 How do people with MCAS present clinically?
5:45 Why is MCAS so poorly recognised within the medical community?
12:22 How do Long Covid patients present?
13:55 How have you treated Long Covid patients?
16:33 How do you clinically test for MCAS?
20:37 What advice do you give your Long Covid patients in terms of management?
26:43 What are the most common triggers you see?
28:10 Are you familiar with the NAD+ deficiency theory? 
REFERENCES:

MCAS and Long Covid, Afrin et al (2020):
https://www.sciencedirect.com/science/article/pii/S1201971220307323

Mast Cells, Wikipedia:
https://en.wikipedia.org/wiki/Mast_cell

Видео The Role of MCAS in Long Covid | With World Leading Specialist Dr Lawrence Afrin канала RUN-DMC