TPM vs TMM Explained | RNA-seq Normalization Formulas Made Simple

Confused about TPM and TMM in RNA-seq normalization? This video breaks down the key formulas in a simple, intuitive way.

We walk through:

📏 How TPM (Transcripts Per Million) is calculated step-by-step
🧮 Why TPM normalizes for gene length and sequencing depth
⚖️ How TMM (Trimmed Mean of M-values) works using weighted averages
🔬 Why TMM is preferred for differential expression analysis
🧠 Key differences between TPM and TMM

You’ll understand not just the formulas, but what they mean biologically and when to use them.

👉 Perfect for students and researchers in bioinformatics, RNA-seq, and genomics

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