The Cytokine Storm: Is This Why COVID Kills?

The Cytokine Storm: Is This Why COVID Kills? | Tocilizumab and Coronavirus | Interleukin-6 (IL-6)

Coronavirus Pandemic: Updates, Informations & Treatments | COVID YouTube Playlist by Dr. Yo:
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A potential cause of Coronavirus aka COVID fatalities is the cytokine storm which is an out of control immune system. What is happening in coronavirus and cytokine storm is your body’s own immune system is betraying you by going into overdrive and attacking COVID and your own healthy cells.

Cytokines are cell-signaling molecules that aid cell to cell communication in immune responses and stimulate the movement of cells towards sites of inflammation, infection, and trauma caused by COVID.

The cytokine network involves several different cell types that coordinate their efforts as part of the immune system. While this complex network can look intimidating at first, the point here is that cytokines may act on the cells that secrete them, called autocrine action, on nearby cells called paracrine action, or in some instances on distant cells called endocrine action. Cytokines can be pro-inflammatory or anti-inflammatory and also be involved with nerve sensitization causing pathologic pain.

Proinflammatory cytokines are produced primarily by activated macrophages and are involved in the up-regulation of inflammatory response.

INTERLEUKIN1β, INTERLEUKIN-6, and TUMOR NECROSIS FACTOR ALPHA are the typical proinflammatory cytokines.

The major anti-inflammatory cytokines include INTERLEUKIN-4, 10, 11, 13, and TRANSFORMING GROWTH FACTOR. Of note, IL-10 is a potent anti-inflammatory cytokine and also suppresses the proinflammatory cytokines such as TNF-α, IL-6, and IL-1

Tocilizumab is a novel monoclonal antibody that competitively inhibits the binding of interleukin-6 (IL-6) to its receptor (IL-6R). Inhibiting the entire receptor complex prevents IL-6 signal transduction to inflammatory mediators that summon B and T cells.
Tocilizumab is already approved by the FDA for the treatment of cytokine release syndrome (CRS) that is severe or life-threatening and they just recently approved a phase 3 clinical trial for COVID pneumonia.

- Dr. Yo

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Видео The Cytokine Storm: Is This Why COVID Kills? канала Dr. Yo