Improving Sleep to Slow the Progression of Alzheimer’s Disease

Join Rohan Jagirdar, PhD as he discusses his research on EEG activity in a mouse model of Alzheimer's disease to determine the effects of improved sleep on disease progression.
Alzheimer’s disease (AD) is associated with memory impairment, cognitive dysfunction and sleep fragmentation. These seemingly disparate symptoms are also observed in transgenic mouse models of AD, and both can be regulated by activity in the corticothalamic network. Rohan’s group has previously found that activity in the thalamic reticular nucleus (TRN) is reduced in transgenic mice that express human amyloid precursor protein (APP), and they investigated whether restoring activity in the TRN affects sleep quality and architecture. They also examined the accumulation of β-amyloid plaques, which has been shown to be modulated by sleep.
During this webinar, Rohan presents the results of his research on the acute activation of the TRN to improve sleep quality in a mouse model of Alzheimer’s disease. He also discusses how chronic TRN activation for 30 days improved sleep quality for the duration of treatment and decreased β-amyloid plaque accumulation in these mice.
Key Topics Include:
- Sleep related issues, including sleep disturbances and lack of sleep maintenance, in Alzheimer’s disease (AD) predict risk of AD years before diagnosis.
- Sleep disturbance and lack of good quality sleep in AD patients has been known for decades, however, precise mechanisms are unclear.
- Thalamic reticular nucleus is a regulatory nucleus that controls thalamo-cortical communication, by gating of peripheral sensory information and maintenance of deep stages of sleep (slow wave sleep).
- Sleep plays a critical role in the equilibrium of both Aβ and tau in the brain, either by enhancing glymphatic clearance or reducing production by an activity-dependent mechanism.
To learn more, go to:
https://insidescientific.com/webinar/improving-sleep-to-slow-the-progression-of-alzheimers-disease/

Видео Improving Sleep to Slow the Progression of Alzheimer’s Disease канала InsideScientific