James R Heath, Virtual COVID 19 Symposium May 11, 2022

James R. Heath, PhD, President and Professor, Institute for Systems Biology in Seattle, Factors that Anticipate Post Acute COVID-19 Sequelae

The Long-COVID-19 Common Manifestations include: neurological, pulmonary, cutaneous, psychiatric and cardiovascular abnormalities. The team’s symptomatic data was collected through direct questionnaires, an validate through comparisons against electronic health records. Anti-spike RBD Abs are seen in nearly all patients, scaling with severity. The team mined patient plasma for protein or metabolomic markers that associate with specific PASC. Measurements are from plasma samples at T3 (at convalescence) for symptoms reported at T3. The overall goal was to simply provide some initial disease definition. Evidence of an altered circadian rhythm (2 proteins) was the only proteomic or metabolic signature found that associates with neurological PASC, and the association was highly significant. Low Cortisol at convalescence is not associated with steroid treatment. Some steroids are chemical similar to cortisol, and can alter cortisol regulation. Viral Loads of SARS-CoV-2 and EBV peak early in COVID-19 infection. Atypical memory cells are B cells that mature to form IgG antibodies, but outside of the normal tissue process that occurs within B cell follicles. They are pretty unusual, but reports on how they are associated with infections, comorbidities, etc are mixed. The team probably resolved type 2 diabetes as a PASC Factor because it is such a common comorbidity. Other comorbidities may be important, but we don't have the statistics to tell (except that congestive heart failure, unsurprisingly, is also a PASC factor).

Видео James R Heath, Virtual COVID 19 Symposium May 11, 2022 канала Herbert Irving Comprehensive Cancer Center at Columbia