WEBINAR - Is moving to BLI worth it ?

Biotherapeutics, such as monoclonal antibodies, bispecific antibodies, Antibody-Drug Conjugates, are complex molecules widely used in the treatment of various diseases, including cancers and auto-immune disorders.

Characterisation and quality control of this class of products require the use of innovative technologies such as Surface Plasmon Resonance (SPR – Biacore, Cytiva) or Bio-Layer Interferometry (BLI – Octet, Sartorius). While SPR is widely accepted and used in a large number of laboratories, BLI is a relatively new technology.

In spite of its new entry on the market, more and more laboratories consider BLI to be a complementary or a substitute technology to SPR. As with SPR, BLI technology offers label-free assays that provide precise and reliable concentration and kinetic measurements. This technology can be applied throughout all stages of product development, from discovery to quality control, including stability studies and batch-to-batch consistency evaluations in a GMP compliant environment.

Our presenter Thomas Henri, Scientist at Quality Assistance, presents our recent analytical advances in this field:

• Principle of the BLI technology
• Presentation of different case studies:
- Binding to the target antigen
- Binding to Fcy and FcRn receptors
- Binding to C1q
- Quantification of an antibody fragment
• Discussion concerning BLI performance

Download the slides of the presentation here: https://www.quality-assistance.com/moving-bli-worth-it-0

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European leader in analytical sciences

Quality Assistance S.A. is a leading European Contract Research Organisation providing the pharmaceutical industry with all the analytical services required by EMA and FDA regulations for the development and marketing of innovative human medicinal products.

We assist our clients from candidate selection, through non-clinical and clinical studies, to marketing authorisation, using our state-of-the-art, product-dedicated expertise in analytical sciences.
For each customer and each project, we design customised solutions, define analytical protocols, develop and validate specific new analytical methods and perform characterisation, stability, pharmacokinetic, biomarker and immunogenicity studies as well as batch release testing, in order to evaluate the Quality, Safety and Efficacy of the given drugs.

Technoparc de Thudinie, 2
6536 Donstiennes
Belgium

www.quality-assistance.com

Видео WEBINAR - Is moving to BLI worth it ? канала Quality Assistance