Ageing Senescence | Developmental Biology | CSIR DBT JRF 2026 | Lec-37 | IFAS

Ageing Senescence explained with clear concepts and exam-focused approach. Master Ageing Senescence in Developmental Biology for CSIR NET & DBT JRF 2026 with PYQs, tricks, and problem-solving.

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Video Timeline
[00:00:00] – Introduction - Ageing Senescence | Developmental Biology
[00:10:48] – Senescence & Hayflick Limit
[00:12:05] – Cellular Senescence Definition
[00:15:00] – Reasons: Somatic Damage
[00:17:05] – Senescence Prevents Cancer
[00:19:39] – Hayflick Limit (40–50 Divisions)
[00:20:01] – Replicative Senescence & P53
[00:22:23] – Exceptions: Stem, Germ, Cancer Cells
[00:25:24] – Causes: Telomere, ROS, Oncogenes
[00:29:40] – Permanent Cell Cycle Arrest
[00:30:08] – P53 Signalling Pathway
[00:31:31] – P53: Arrest, Repair, Apoptosis
[00:33:43] – RB & G1 Arrest
[00:34:19] – Telomere Shortening Irreparable
[00:35:54] – P53: Senescence vs Apoptosis
[00:37:20] – Senescence Leads to Aging
[00:38:38] – Aging: Physiological Deterioration
[00:39:26] – Aging is Biological, Not Disease
[00:40:03] – Stem Cell Pool Decline
[00:44:39] – Factors: Damage & Stress
[00:46:07] – Senescence/Apoptosis Promotes Aging
[00:49:20] – Fast vs Slow Aging
[00:53:55] – Rat vs Human Aging Example
[00:55:59] – Somatic Maintenance Slows Aging
[00:57:34] – Factor 1: Antioxidant-Rich Diet
[01:01:05] – Factor 2: Stress Environment
[01:06:00] – Factor 3: Caloric Intake & Insulin
[01:08:25] – Factor 4: Mutagens & Pollution
[01:09:59] – Gene: Lamin A (Progeria)
[01:11:36] – Gene: Klotho (Insulin Regulator)
[01:12:51] – Gene: P53 (DNA Damage Control)
[01:14:25] – Gene: Sirtuins (HDAC)
[01:18:05] – Gene: FOXO (Longevity)
[01:19:09] – Gene: mTOR (Growth)
[01:19:25] – Gene: IGF-1 Receptor
[01:20:09] – Werner Syndrome & Repair
[01:20:30] – APOE & Alzheimer’s
[01:20:52] – NF‑κB & Inflammation
[01:21:01] – Telomerase & Aging
[01:29:44] – Question 1: ABCD Model – Unisexual Flower
[01:34:01] – Complete Session (Ageing Senescence | Developmental Biology)

Topics Covered
• Ageing vs Senescence Concepts
• Cellular Senescence & Hayflick Limit
• Telomere Theory & Replicative Ageing
• Programmed & Damage Theories
• CSIR PYQs & Problem-Solving Tricks

Lecture Summary
In this session, IFAS Expert Faculty focuses on Ageing Senescence, covering cellular senescence, Hayflick limit, telomere theory, and damage theories. Discusses oxidative stress, apoptosis vs senescence, and replicative ageing. Learn problem-solving tricks with CSIR NET & DBT JRF PYQs. Master Ageing Senescence concepts crucial for Developmental Biology.

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Видео Ageing Senescence | Developmental Biology | CSIR DBT JRF 2026 | Lec-37 | IFAS канала IFAS LIFESCIENCE LIVE - CSIR, UGC, DBT, GATE, SET