The Great American Drug Deal Explained

I discuss “The Great American Drug Deal”, a book about the U.S. pharmaceutical industry written by Peter Kolchinsky 📚💊🤝
Want to learn about the tricks “Bad Pharma” uses to make billions? Watch this 👉 https://www.youtube.com/watch?v=L03ICf_vh80&list=UULFCWndUzziarMjA4pDG1ps2A&t=5s
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TIMECODES ⏰
0:00 Intro & Background
1:30 Agenda / Topics in this Video
1:37 The Biotech Social Contract
3:27 Generic Drug Armamentarium
5:17 Branded Drugs as an Investment
6:38 How America Breaks the Contract
10:40 Pharmacy Benefit Managers
12:55 Contractual Genericization
15:10 Price-Jacking of Off-Patent Drugs
16:03 Lower Drug Pricing in Other Countries Outside the U.S.
19:27 Direct-to-Consumer Advertising (DTCA)
21:27 Short Exclusivity Extensions
23:55 Looking for a Different Perspective on Pharma?
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REFERENCES 📚
The Great American Drug Deal: A New Prescription for Innovative and Affordable Medicines (by Peter Kolchinsky):
https://www.amazon.co.uk/Great-American-Drug-Deal-Prescription/dp/1733058915
Prescription Drug Prices in the US versus other countries:
https://www.rand.org/news/press/2024/02/01.html
Finegold, K., Conmy, A., Chu, R. C., Bosworth, A., & Sommers, B. D. (2021). Trends in the USUSninsured population. Washington, DC: Office of the Assistant Secretary for Planning and Evaluation. Available here: https://aspe.hhs.gov/sites/default/files/private/pdf/265041/trends-in-the-us-uninsured.pdf
Top 10 Pharma Markets (IQVIA data):
https://www.iqvia.com/-/media/iqvia/pdfs/canada/2023-trends/english/top10worldwidesales_23.pdf
Life Expectancy vs. Health Expenditure:
https://ourworldindata.org/financing-healthcare
Mulcahy AW, Schwam D, Lovejoy SL. International Prescription Drug Price Comparisons: Estimates Using 2022 Data. Rand Health Q. 2024 Jun 3;11(3):5. PMID: 38855386; PMCID: PMC11147645. Available here: https://pmc.ncbi.nlm.nih.gov/articles/PMC11147645/
Struggling With Errors, DOGE Deletes Billions More From List of Savings. Available here:
https://www.nytimes.com/2025/03/03/us/politics/doge-musk-contracts-wall.html
Shrank, W. H., Rogstad, T. L., & Parekh, N. (2019). Waste in the US health care system: estimated costs and potential for savings. Jama, 322(15), 1501-1509. Available here: https://jamanetwork.com/journals/jama/article-abstract/2752664?casa_token=pYst8zl_6E8AAAAA:uAW_fHHwipOx7F5IFlr2_bJJQOhnA70ludELkcXXFdaxvmTnPBdxQHBRNwE_LjU37beQM1WFPw&casa_token=0tzr0ACzhcYAAAAA:j4F9A-tkOFsOj84OFNSkQOIFI7v9A-oYinFKunqFY0C4uBYnqMMuUInW9U3EBDm1AHV9ntUZ9A
ABPI Patent Protection Graphic:
https://www.abpi.org.uk/international-trade-and-ip/intellectual-property-ip/intellectual-property-enabling-next-generation-innovation/
Dieleman, J. L., Squires, E., Bui, A. L., Campbell, M., Chapin, A., Hamavid, H., ... & Murray, C. J. (2017). Factors associated with increases in US health care spending, 1996-2013. Jama, 318(17), 1668-1678.
Health Insurance Coverage in the United States: 2023 Current Population Reports. Available here: https://www.census.gov/library/publications/2024/demo/p60-284.html#:~:text=Of%20the%20subtypes%20of%20health,percent)%2C%20and%20VA%20and%20CHAMPVA
Patient Education: From medical paternalism to patient-centred care. Available here:
https://medium.com/medudoc/patient-education-from-medical-paternalism-to-patient-centred-care-66aec801da13
Seeley, E., & Kesselheim, A. S. (2019). Pharmacy benefit managers: practices, controversies, and what lies ahead. Issue Brief (Commonw Fund), 2019, 1-11.
Mattingly, T. J., Hyman, D. A., & Bai, G. (2023, November). Pharmacy benefit managers: History, business practices, economics, and policy. In JAMA Health Forum (Vol. 4, No. 11, pp. e233804-e233804). American Medical Association.
Rome, B. N., Egilman, A. C., & Kesselheim, A. S. (2022). Trends in prescription drug launch prices, 2008-2021. JAMA, 327(21), 2145-2147.
Woolf, S. H., Grol, R., Hutchinson, A., Eccles, M., & Grimshaw, J. (1999). Potential benefits, limitations, and harms of clinical guidelines. Bmj, 318(7182), 527-530.
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HASHTAGS 🏷️
#USHealthcare #DrugPricing #PharmaEconomics

Видео The Great American Drug Deal Explained канала Mirko von Hein