Special lecture: Paul W. O'Toole, PhD - Gut microbiota in health, disease and aging

In a baseline analysis of the faecal microbiota composition of 161 older persons, we previously reported a core microbiota and aggregate composition that was distinct from younger persons. We also identified significant inter-individual variation at phylum level, the reasons for which were then unclear. To investigate further, we analyzed the microbiota composition of 178 elderly subjects, none receiving antibiotics, and for whom we had collected dietary intake information. The data revealed distinct microbiota composition groups that correlated with residence location. Clustering of subjects by diet produced clusters that overlapped with the microbiota-based clusters, which were also distinguishable by analysis of faecal metabolites. Major separations in the microbiota correlated with selected clinical measurements. Novel constellations of microbiota subtypes were identified, in which differential abundance changed from the healthy to the frail ends of the cohort phenotype spectrum. Collectively the data suggest a relationship between diet, microbiota and health status, and that modulation of the microbiota by dietary adjustment could be used to promote healthy aging.

Видео Special lecture: Paul W. O'Toole, PhD - Gut microbiota in health, disease and aging канала CIC bioGUNE