A Four Hour Conversation With Dr. David Nichols

The greatest living psychedelic chemist Dr. David E. Nichols tells the story of his life in research while synthesizing a novel lysergamide

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--- Chapters ---

00:00 - Intro
09:27 - https://www.lucy.co/
10:33 - Theme
11:12 - Getting Interested in Chemistry
13:14 - Stink B*mb
16:14 - Nitrogen Triiodide
21:15 - https://www.toptreeherbs.com
21:49 - Getting interested in Medicinal Chemistry
22:25 - Counter culture Influence
23:51 - Dr. Nichol’s Parents
26:25 - Interest in Consciousness through “reefer”
28:23 - https://apolloneuro.com
30:15 - Researching Psychedelics Among Cultural Stigma
32:52 - Apomorphine Research
37:22 - Graduate Research
44:16 - Pharmacology Post-Doc
47:15 - Purdue
49:10 - Dopamine Agonists
51:11 - https://matcha.com/
52:13 - Influence of Alexander Shulgin
54:17 - Correspondence with Sasha
57:58 - Psychedelic Research Onus
1:01:35 - Should Everyone Test Compounds Like Shulgin?
1:03:06 - Reading Reports On Compounds He’s Researched
1:03:44 - How to Determine if a Compound Is Psychedelic?
1:04:58 - Why is the Psychedelic Effect Even Possible?
1:07:30 - Are Psychedelics Good, Toxic, or Beneficial in the Evolutionary Sense?
1:10:44 - Psychedelics Attract Really Weird People
1:12:37 - Feeling Compelled to Distribute Psychedelics
1:14:03 - What Was It Like Having Your Drugs End Up on The Grey Market?
1:16:58 - Compounds Being Made Available By Chinese Labs
1:17:52 - Did You Predict The Grey Market?
1:22:21 - How Did You Navigate the Regulations?
1:29:34 - Psychedelic Pharmaceuticals Companies
1:32:27 - Is Medicalization Missing the Point?
1:33:35 - History of Psychedelic Legalization Attempts
1:38:29 - Will Studying Psychedelics Elucidate Consciousness?
1:42:04 - What Needs To Be Done Scientifically?
1:45:13 - Dr. Nichol’s Personal Psychedelic Experiences
1:46:49 - Did You Ever Trip With Shulgin?
1:47:25 - Purdue Research
1:50:19 - Making MDMA and DMT for Doblin and Strassman
1:55:53 - How did you make the DMT?
1:56:08 - What is the Largest Scale Synthesis you’ve Done?
1:58:42 - Making LSD for Brian Roth?
2:02:22 - Roth’s Ultra-LSD
2:03:27 - Scene Change: Reading Old Shulgin Correspondence
2:04:13 - Ted Shulgin’s Ashes
2:04:46 - Shulgin’s Letters
2:10:20 - Ariadne
2:13:18 - Might Publish His Correspondence
2:14:00 - Were Other Researchers As Forthcoming As Shulgin?
2:14:30 - TiHKAL
2:16:42 - Political Implication of TiHKAL
2:22:13 - FOIA on Shulgin
2:22:47 - Did the Shulgin Raid Scare You?
2:25:33 - Shulgin Didn’t Deserve To Be Raided
2:27:21 - Has Your Understanding Of the Site of Action of LSD Changed Over the Years?
2:29:11 - Connection Between Psychedelics and Music?
2:30:00 - Scene Change: The Laboratory
2:30:24 - Hofmann’s Discovery of LSD
2:34:12 - LaBerge and Patty Mulligan
2:39:04 - Lysergamide Evaluations in TiHKAL
2:41:42 - Nick Sand
2:42:30 - Dr. Nichol’s Purifies a Lysergamide on the Chromatotron
2:43:01 - Fluorescence and Psychedelics Activity
2:46:23 - The Psychedelic Guide to the Preparation of the Eucharist
2:47:50 - Bryan Roth In Silico
2:48:58 - Why Did Fungus Evolve to Produce Serotonergic Compounds
2:51:15 - Thio-Compounds
2:53:49 - Alephs
2:56:24 - Toxic Effects of Amphetamine Compounds
2:58:34 - Why is Amphetamine More Toxic Than MDMA?
2:59:58 - Destroying His Compounds
3:01:41 - Psychedelics and Anti-Inflammation
3:02:44 - Rivalry with Glennon
3:04:22 - Can Researchers Take Psychedelics?
3:07:08 - Chloroethyl Tryptamines
3:09:08 - Moving From Purdue
3:12:45 - Love Story with his Wife
3:19:26 - Will you make more Selenium Compounds?
3:21:30 - MDMA as a Parkinson’s Treatment (UWA-101)
3:24:14 - John Wang Faked His Thesis
3:25:49 - David Olson
3:26:55 - Psychedelics Without the Psychedelic Effect
3:29:25 - Pharmaceutical Ketamine
3:30:13 - Upjohn
3:32:37 - Pindolol
3:33:33 - Mescaline Metabolite
3:34:42 - 5-MeO-pyr-T
3:38:53 - 5-HT1A Psychedelics
3:39:39 - Head Twitch Response
3:42:32 - 2-bromo-LSD and Cluster Headaches
3:32:33 - Daniel Trachsel
3:44:42 - Is there a Compound that you’ve wanted to Synthesize and Haven’t?
3:48:37 - Replicated Other’s Past Work
3:49:04 - What do you Think of Neuroimaging?
3:51:34 - There’s Nothing Immoral About Taking A Drug
3:52:58 - Learning From Experience Reports
3:55:03 - Self-Experimentation
3:56:00 - Drugs are Thought to be Bad because they Cause Pleasure
4:01:29 - Negative Beliefs Cause Negative Experiences

Видео A Four Hour Conversation With Dr. David Nichols канала Hamilton Morris