3D Animation video of how Remdesivir works

Medical animation produced by : https://www.scientificanimations.com/
In conjunction with : https://covidindia.org/

CORRECTION: at 1:01 the video says " A key enzyme in this process is RNA polymerase " it should be " RNA Dependent RNA Polymerase "

Disclaimer: All the scenes and explanations in this video are visualized from publicly available news and medical journal articles. For a list of sources, please see below. This animation was not made or in collaboration with Gilead Sciences, the manufacturer of Remdesivir and has not gone through a medical review. This animation does not seek to give medical advice or make medical conclusions but rather visualizes the existing information available on Remdesivir. No payment was made for this animation, it is a public service effort.

Mechanism of Action Transcript:
The most promising potential treatment for Covid-19 is Remdesivir. In studies, it has already shown effectiveness against MERS (Middle East Respiratory Syndrome) a similar coronavirus. Originally developed for ebola, Remdesivir is already in 4 late-stage trials. This is the Mechanism of Action for Remdesivir.

In order to thrive, viruses have four hurdles they need to overcome. Transmission they have to transmit from host to host. Access, they need to bypass the security system of the human cell. Replication, a virus must hijack the cell’s copy machinery to create copies of itself. And Apoptosis, it needs to destroy the cell, and move out to infect other cells.

The genetic encoding of the SARS 2 coronavirus is a single-stranded RNA. After cell entry, the virus co-opts the cell into producing copies. A key enzyme in this process is RNA polymerase which synthesis the nucleotide components that make up the RNA strand. Remdesivir appears to this enzyme as Adenosine one of the nucleotides. The RNA polymerase grabs Remdesivir and attaches it to the chain. But after doing so, further nucleotides are unable to attach, thereby terminating the replication process.

By preventing the completion of the replication process, Remdesivir stops the pathogenesis for SARS-Coronavirus-2 .

Sources:
https://www.statnews.com/2020/03/16/remdesivir-surges-ahead-against-coronavirus/

https://www.nature.com/articles/s41422-020-0282-0

https://www.asbmb.org/asbmb-today/science/031720/what-makes-remdesivir-a-promising-antiviral

https://en.wikipedia.org/wiki/Remdesivir

https://www.ncbi.nlm.nih.gov/pubmed/30987343
Acknowledgments: VO provided by Yasmine Tanres

Видео 3D Animation video of how Remdesivir works канала Scientific Animations