○ Meet p53 - the guardian of the genome 🧬🛡️

Introducing p53, the guardian of the genome. 🧬🛡️

Upon detection of DNA damage, a single protein, p53, determines the cellular outcome. Its primary function is to safeguard against oncogenesis. 🚫🔬

The operational mechanism of p53 is as follows:

1. **DNA Damage Detection:** The presence of DNA damage is identified. 🚨
2. **p53 Upregulation:** Intracellular p53 levels rapidly increase. 📈
3. **Cell Cycle Arrest:** p53 initiates a halt in the cell cycle at the G1/S checkpoint, providing an opportunity for DNA repair. ⏸️🩹
4. **DNA Repair Activation:** Genes associated with DNA repair pathways are activated. 🛠️
5. **Apoptosis (if damage is irreparable):** p53 triggers programmed cell death, thereby preventing the proliferation of mutated cells. 💀🔥

The absence or mutation of p53 leads to the uncontrolled division of damaged cells. This critical role explains why p53 is found to be mutated in approximately 50% of human cancers. 💔🦠

In essence, p53 dictates whether a cell undergoes repair or sacrifices itself for the collective benefit of the organism. ⚖️❤️

Видео ○ Meet p53 - the guardian of the genome 🧬🛡️ канала EXPLOR