Hepatitis C in Pregnancy | Vertical Transmission & Management | Prof. Dr. J.B. Sharma| OBG Residency

Understanding Hepatitis C in pregnancy is crucial for every OBG resident.

In this quick revision, we cover all high-yield exam points:

🦠 HCV Basics
• RNA virus with ~50% risk of chronic infection
• Often asymptomatic (up to 75%)

⚠️ Complications
• Cirrhosis
• Hepatocellular carcinoma
• B-cell lymphoma
• Cryoglobulinemia

🧪 Diagnosis
• Screening: Anti-HCV antibodies
• Confirmatory: HCV RNA (PCR)

👶 Vertical Transmission
• Risk: 2–8% (can rise up to 10–44% with risk factors)
• Requires maternal viremia
• Risk factors:
– High viral load
– Prolonged rupture of membranes
– Internal fetal monitoring
– HIV co-infection

🚫 Management in Pregnancy
• No routine treatment (avoid antivirals like ribavirin/interferon)
• No proven prevention of transmission
• Cesarean section does NOT reduce risk
• Breastfeeding is NOT contraindicated

👶 Infant Follow-up
• HCV RNA testing at 6 months
• Antibody testing after 12–18 months

📌 Screening Recommendations
Not universal—focus on high-risk groups (IV drug use, transfusions, dialysis, etc.)
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[ obstetrics and gynecology residency, ob gyn residency programs, best obstetrics and gynecology residency programs, obgyn residents, hepatitis C in pregnancy, HCV vertical transmission, antenatal infections, viral hepatitis pregnancy, OBG viva prep, pregnancy infections management, maternal fetal medicine, medical residency, gynecology concepts, high risk pregnancy, HCV screening guidelines ]

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