Introduction to Chemical Biology 128. Lecture 06. DNA Reactivity with Small Molecules.

UCI Chem 128 Introduction to Chemical Biology (Winter 2013)
Lec 06. Introduction to Chemical Biology -- DNA Reactivity with Small Molecules
View the complete course: http://ocw.uci.edu/courses/chem_128_introduction_to_chemical_biology.html
Instructor: Gregory Weiss, Ph.D.

License: Creative Commons BY-NC-SA
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Description: Introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways.

Introduction to Chemical Biology (Chem 128) is part of OpenChem: http://ocw.uci.edu/collections/open_chemistry.html
This video is part of a 18-lecture undergraduate-level course titled "Introduction to Chemical Biology" taught at UC Irvine by Professor Gregory Weiss.

Recorded on January 24, 2013.

Index of Topics:
0:01:53 Examples of DNA Intercalators
0:04:21 How to Measure and Calculate the Strength of DNA Hyrbidization
0:09:20 Short Stretches of DNA & RNA Can Also Fold
0:10:31 DNA is Wound into Supercoils
0:15:53 Bacterial DNA is Stored in Plasmids
0:18:29 Antibiotics as Selection Markers
0:22:24 Eukaryotic DNA is Wrapped Around Nucleosomes
0:27:24 Trapoxin as a Highly Specific HDCA-1 Inhibitor
0:28:49 Biological Polynucleotide Synthesis
0:32:07 DNA Polymerases
0:46:57 RT Inhibitors
0:52:15 A Brief HIstory of Chemical DNA Synthesis
0:57:01 The DNA Microarray
1:02:09 FK506 Fingerprinting
1:03:58 Analysis of DNA by Electrophoresis
1:07:55 DNA Sequencing Uses DNA Synthesis
1:10:37 DNA Biotechnology

Required attribution: Weiss, Gregory Introduction to Chemical Biology 128 (UCI OpenCourseWare: University of California, Irvine), http://ocw.uci.edu/courses/chem_128_introduction_to_chemical_biology.html. [Access date]. License: Creative Commons Attribution-ShareAlike 3.0 United States License (http://creativecommons.org/licenses/by-sa/3.0/us/deed.en_US).

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