SOP - The Architect's Guide to Chromosome-Level Genome Assembly | V00419

SOP - The Architect's Guide to Chromosome-Level Genome Assembly | V00419

This video outlines a Standard Operating Procedure for constructing highly accurate, chromosome-level genome assemblies. The protocol utilizes a hybrid sequencing strategy that merges the structural advantages of long-read sequencing with the high-fidelity accuracy of short-read data. A critical component of the workflow involves Hi-C scaffolding, which allows researchers to organize genetic material into full-scale chromosomes by analyzing spatial chromatin interactions. The guide identifies specific bioinformatics tools, such as Flye and Juicebox, to assist in the polishing, mapping, and visualization of the genomic data. Ultimately, this comprehensive technical framework ensures that researchers can produce refined genetic maps for a diverse range of organisms, including plants and animals.
#Genomics
#Bioinformatics
#GenomeAssembly
#HybridSequencing
#HiC
#ChromosomeLevel
#DNASequencing
#Scaffolding

Видео SOP - The Architect's Guide to Chromosome-Level Genome Assembly | V00419 канала Computational GenomeBiology