GLEEVEC (IMATINIB) MOA
Kit is a receptor tyrosine kinase that activates of a number of pathways that direct cell proliferation, survival, and apoptosis. Mutations in Kit that result in constitutive oligomerization in the absence of ligand can drive continuous oncogenic signaling. The majority of gastrointestinal stromal tumor (GIST) cells have been found to present with overactive Kit signaling. Gleevec, or Glivec (imatinib mesylate) competitively binds to the ATP binding pocket of both active and inactive Kit, preventing downstream signaling. Kit inhibition by imatinib may induce both apoptosis and quiescence in KIT+ GIST cells.
Видео GLEEVEC (IMATINIB) MOA канала XVIVO Scientific Animation
Видео GLEEVEC (IMATINIB) MOA канала XVIVO Scientific Animation
Показать
Комментарии отсутствуют
Информация о видео
1 февраля 2021 г. 22:00:05
00:03:33
Другие видео канала
![Glutamate Modulation](https://i.ytimg.com/vi/bAmb42zpRls/default.jpg)
![Three Types of Targeted Therapy and How They Work](https://i.ytimg.com/vi/VrlBD32RPpM/default.jpg)
![The Immune System Explained I – Bacteria Infection](https://i.ytimg.com/vi/zQGOcOUBi6s/default.jpg)
![Cell signalling: kinases & phosphorylation](https://i.ytimg.com/vi/xG2WOd_fWqo/default.jpg)
!['표적항암치료'를 통해 암을 극복하는 방법 5 - 혈액종양내과 김찬,전홍재 교수](https://i.ytimg.com/vi/9x78w2RNXOs/default.jpg)
![Methotrexate - Pharmacology (DMARDs, mechanism of action, side effects)](https://i.ytimg.com/vi/2k4-NuFjto0/default.jpg)
![PROTAC™ PLATFORM](https://i.ytimg.com/vi/7vSAGU4JCTM/default.jpg)
![COBRA PLATFORM MOA](https://i.ytimg.com/vi/dZFKZ_kLzuk/default.jpg)
![MEDTRONIC SACRAL NEUROMODULATION](https://i.ytimg.com/vi/hLrB8EJL0eg/default.jpg)
![400mg imatinib as good as 800mg for 10 year CML survival](https://i.ytimg.com/vi/rs6SrjXspyY/default.jpg)
![The Inner Life of the Cell](https://i.ytimg.com/vi/wJyUtbn0O5Y/default.jpg)
![How Gleevec® Works](https://i.ytimg.com/vi/7YikgO4--sM/default.jpg)
![How Gleevec Works - HHMI](https://i.ytimg.com/vi/gin_pSgpPhk/default.jpg)
![Gleevec: Mechanism of Action](https://i.ytimg.com/vi/nP8-9WWp5ZQ/default.jpg)
![Drug discovery and development process](https://i.ytimg.com/vi/3Gl0gAcW8rw/default.jpg)
![STRATTICE RECONSTRUCTIVE TISSUE MATRIX](https://i.ytimg.com/vi/1yE72StI5fM/default.jpg)
![Tyrosine Kinase Inhibitors (TKIs) | Philadelphia Chromosome| CML and ALL](https://i.ytimg.com/vi/c5uY_iTNLCU/default.jpg)
![TUMOR TREATING FIELDS](https://i.ytimg.com/vi/08L6B63VezE/default.jpg)
![CONDUIT™ INTERBODY PLATFORM](https://i.ytimg.com/vi/RV2b5cYvoy8/default.jpg)
![Ovulation - Nucleus Health](https://i.ytimg.com/vi/nLmg4wSHdxQ/default.jpg)