Addison disease #biochemistrytamil

🩺 ADDISON DISEASE (ADRENAL FAILURE)

Addison disease என்பது adrenal insufficiency condition.
இதில் adrenal gland proper-ah function panna mudiyama:

cortisol decrease aagum

aldosterone (mineralocorticoid) decrease aagum
📌 Causes: ✅ Primary adrenal failure → adrenal gland destruction
✅ Secondary adrenal failure → pituitary ACTH deficiency

📌 Important Tests: 🧪 Basal morning cortisol (8–9 AM)
🧪 ACTH stimulation test – gold standard test

📌 Key Laboratory Findings: ⬇️ Cortisol
⬇️ Sodium (Na⁺)
⬇️ Glucose
⬆️ Potassium (K⁺)
⬆️ ACTH in primary adrenal insufficiency

📌 Clinical Importance: Early diagnosis life-threatening adrenal crisis-ah prevent panna help pannum.

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