Single cell multiomic analysis of T-cell exhaustion

Presented By: Pratip K. Chattopadhyay, PhD

Speaker Biography: Pratip Chattopadhyay, PhD is an Associate Professor (Pathology) and founding Director of NYU Langone Health's Precision Immunology Laboratory (PIL). His laboratory performs independent research in tumor immunology and provides cutting-edge immune monitoring services for a wide variety of biomedical disciplines (cancer, infectious disease, rheumatology).

Webinar: Single cell multiomic analysis of T-cell exhaustion

Webinar Abstract: A key step in the clinical production of CAR T cells is the expansion of engineered T cells. To generate enough cells for viable adoptive cell therapy, cells must be robustly stimulated, which raises the risk of inducing T-cell exhaustion and reducing therapeutic efficacy. We sought to answer fundamental questions about the impact of in vitro manipulation on T-cell identity to by performing single-cell multiomic analysis using BD® AbSeq and BD Rhapsody™ Single-Cell Analysis system to simultaneously measure expression of 38 proteins and 399 genes in human T cells expanded in vitro.

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Видео Single cell multiomic analysis of T-cell exhaustion канала Labroots