Isoniazid - A narrow spectrum antibiotic for tuberculosis

Isoniazid (INH) is a narrow spectrum antibiotic used in the treatment of tuberculosis. This drug is a nicotinic acid derivative with hydrazide as functional group.

Isoniazid is a prodrug that is activated within the mycobacterial cell by one of the important enzyme catalase-peroxidase in presence of hydrogen peroxide. This enzyme is coded by the gene Kat G which can be mutated by the organism to produce resistance.

Finally this drug forms an adduct with NADH molecules which inhibits synthesis of mycolic acid within the mycobacteria.

#INH
#KatG
#InhA

Видео Isoniazid - A narrow spectrum antibiotic for tuberculosis канала eGPAT