Neurodegenerative Diseases

Neurodegenerative diseases are characterized by the degeneration and death of neurons. In this video, I first discuss some general characteristics and common pathologies of neurodegenerative diseases. Then, I go into more detail with five examples of neurodegenerative diseases: Parkinson's Disease, Huntington's disease, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS).

0:02 General info about neurodegenerative diseases
0:45 Pathological hallmarks of neurodegenerative diseases
2:23 Parkinson's disease
4:15 Huntington's disease
6:05 Alzheimer's disease
7:56 Amyotrophic lateral sclerosis (ALS)
9:44 Multiple sclerosis (MS)

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📚Bizarre: The Most Peculiar Cases of Human Behavior and What They Tell Us About How the Brain Works: https://www.amazon.com/Bizarre-Peculiar-Cases-Human-Behavior/dp/139980121X/

REFERENCES
Morgan S, Orrell RW. Pathogenesis of amyotrophic lateral sclerosis. Br Med Bull. 2016
Sep;119(1):87-98. doi: 10.1093/bmb/ldw026.

Przedborski S, Vila M, Jackson-Lewis V. Neurodegeneration: what is it and where are we? J Clin Invest. 2003 Jan;111(1):3-10. doi: 10.1172/JCI17522. PMID: 12511579; PMCID: PMC151843.

Purves D, Augustine GJ, Fitzpatrick D, Hall WC, Lamantia AS, McNamara JO, White LE. Neuroscience. 4th ed. Sunderland, MA. Sinauer Associates; 2008.

Rothstein JD. Current hypotheses for the underlying biology of amyotrophic lateral sclerosis. Ann Neurol. 2009 Jan;65 Suppl 1:S3-9. doi: 10.1002/ana.21543.

Walker FO. Huntington's disease. Lancet. 2007 Jan 20;369(9557):218-28.

Wilson DM 3rd, Cookson MR, Van Den Bosch L, Zetterberg H, Holtzman DM, Dewachter I. Hallmarks of neurodegenerative diseases. Cell. 2023 Feb 16;186(4):693-714. doi: 10.1016/j.cell.2022.12.032. PMID: 36803602.

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My name is Marc, and I want to immerse you in the fascinating world of neuroscience. When I'm not making videos, I'm a university professor at Penn State. I made this channel to help simplify complex topics into easy-to-understand snippets, perfect for students & enthusiasts alike. 📚

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Видео Neurodegenerative Diseases канала Neuroscientifically Challenged