Long Covid Associated with Elevated Interferon Levels

Roger Seheult, MD of MedCram explores elevated interferon levels associated with long covid. See all Dr. Seheult's videos at: https://www.medcram.com/

(This video was recorded on February 23rd, 2024)

Roger Seheult, MD is the co-founder and lead professor at https://www.medcram.com/

He is Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine and an Associate Professor at the University of California, Riverside School of Medicine.
LINKS / REFERENCES:

Spontaneous, persistent, T cell–dependent IFN-γ release in patients who progress to Long Covid (Science Advances) | https://www.science.org/doi/10.1126/sciadv.adi9379

Viruses and interferon: a fight for supremacy (Nature) | https://www.nature.com/articles/nri888

Interferon Responses Could Explain Susceptibility to Severe COVID-19 (Medium) | https://medium.com/swlh/interferon-responses-could-explain-susceptibility-to-severe-covid-19-cc69a654b999

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients (Science) | https://www.science.org/doi/10.1126/science.abc6027

Examination of autoantibodies to type I interferon in patients suffering from long COVID (Journal of medical virology) | https://pubmed.ncbi.nlm.nih.gov/37698062/

SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in cell culture and in mice (PNAS) | https://www.pnas.org/doi/10.1073/pnas.2302083120

Early Treatment with Pegylated Interferon Lambda for Covid-19 (NEJM) | https://www.nejm.org/doi/full/10.1056/NEJMoa2209760

Hyperthermia in humans enhances interferon-gamma synthesis and alters the peripheral lymphocyte population (Journal of interferon research) | https://pubmed.ncbi.nlm.nih.gov/3132509/

The biological activity of interferons in post-COVID syndrome (ERJ) | https://openres.ersjournals.com/content/8/suppl_8/240

Prevalence of persistent SARS-CoV-2 in a large community surveillance study (Nature) | https://www.nature.com/articles/s41586-024-07029-4#Sec2

Interferon Response in Hepatitis C Virus-Infected Hepatocytes: Issues to Consider in the Era of Direct-Acting Antivirals (International journal of molecular sciences) | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177520/

Treatment of hepatitis C virus infection with interferon and small molecule direct antivirals: viral kinetics and modeling (Critical reviews in immunology) | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882097/
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Video Produced by Kyle Allred
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